{"id":"W3006119534","doi":"10.1016/j.biopsych.2020.02.001","title":"The β-Secretase BACE1 in Alzheimer’s Disease","year":2020,"lang":"en","type":"review","venue":"Biological Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":666,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; GE Healthcare; Fondation pour la Recherche sur Alzheimer; AXA Research Fund; Rosetrees Trust; Roche; Agence Nationale de la Recherche; Sorbonne Université; Servier; Association Sorbonne Université; Eisai; Parkinson's UK; Oryzon Genomics; Fanconi Anemia Research Fund; Pfizer; Eisai Incorporated; Johnson and Johnson; Takeda Pharmaceutical Company; Eli Lilly and Company; Medical Research Council; Biogen","keywords":"BACE1-AS; Amyloid precursor protein secretase; Amyloid precursor protein; Enzyme; Amyloid (mycology); Biochemistry; Chemistry; Alzheimer's disease; P3 peptide; Biochemistry of Alzheimer's disease; Disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002176683,0.0005671863,0.001463783,0.00009097869,0.0001750663,0.0000472931,0.0004079302,0.000355452,0.0002258951],"category_scores_gemma":[0.0002242704,0.0002611331,0.001042602,0.0004815619,0.0002872318,0.00002774611,0.0001916075,0.0009438713,0.00135045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000899825,"about_ca_system_score_gemma":0.001688904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000851492,"about_ca_topic_score_gemma":0.000006024259,"domain_scores_codex":[0.9970602,0.0004508358,0.0006676485,0.0007867304,0.0003596153,0.0006749671],"domain_scores_gemma":[0.9975189,0.000304956,0.0001813699,0.0006854927,0.00003283567,0.001276436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007969344,0.001012739,0.008126633,0.001880732,0.008942286,0.001301241,0.000003226016,2.123817e-8,7.852598e-9,0.001571591,0.009846571,0.966518],"study_design_scores_gemma":[0.0007377981,0.000355183,0.002641354,0.002577395,0.003100182,0.00002853802,0.00001259637,0.000002496407,9.612495e-9,0.0006466188,0.9896123,0.000285546],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001709389,0.9939407,6.364114e-7,0.002274835,0.0004086871,0.002109764,0.0002744422,0.00008889605,0.0008850151],"genre_scores_gemma":[0.0002921115,0.9972628,0.00009581738,0.000367372,0.0006405049,0.0004485845,0.0008266278,0.00004703319,0.00001919536],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9797657,"threshold_uncertainty_score":0.9999841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1367854921733183,"score_gpt":0.4070675391148329,"score_spread":0.2702820469415146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}