{"id":"W3006119534","doi":"10.1016/j.biopsych.2020.02.001","title":"The β-Secretase BACE1 in Alzheimer’s Disease","year":2020,"lang":"en","type":"review","venue":"Biological Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":666,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; GE Healthcare; Fondation pour la Recherche sur Alzheimer; AXA Research Fund; Rosetrees Trust; Roche; Agence Nationale de la Recherche; Sorbonne Université; Servier; Association Sorbonne Université; Eisai; Parkinson's UK; Oryzon Genomics; Fanconi Anemia Research Fund; Pfizer; Eisai Incorporated; Johnson and Johnson; Takeda Pharmaceutical Company; Eli Lilly and Company; Medical Research Council; Biogen","keywords":"BACE1-AS; Amyloid precursor protein secretase; Amyloid precursor protein; Enzyme; Amyloid (mycology); Biochemistry; Chemistry; Alzheimer's disease; P3 peptide; Biochemistry of Alzheimer's disease; Disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005899871,0.001050676,0.001978409,0.001901869,0.0002068623,0.001066373,0.0007437345,0.001136842,0.005518787],"category_scores_gemma":[0.0009123324,0.0002907964,0.0005501744,0.002079948,0.000379741,0.001229736,0.000716041,0.001841778,0.00238445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006025901,"about_ca_system_score_gemma":0.001163412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001440589,"about_ca_topic_score_gemma":0.002727888,"domain_scores_codex":[0.9998524,0.0000229655,0.00002962737,0.00002187253,0.00005587196,0.00001718379],"domain_scores_gemma":[0.9997423,0.0001133388,0.00005540247,0.000006689505,0.00005802863,0.00002415007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002380317,0.00007197829,0.0001104977,0.02839543,0.000219888,0.0001566181,0.00003190227,0.000276482,0.001592328,0.002004754,0.03308018,0.9338219],"study_design_scores_gemma":[0.0001977567,0.0002261274,0.00106181,0.008033521,0.0007071514,0.0009964836,0.00005690697,0.000132021,0.0005864213,0.002406611,0.9855683,0.0000268978],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004587905,0.9993174,0.00003329306,0.0001139713,0.0001189251,0.000002529993,0.00001209946,0.000002787987,0.000353175],"genre_scores_gemma":[0.000374943,0.9989669,0.00006204761,0.000125546,0.0001149403,0.000003705588,0.00001994242,5.557494e-7,0.0003314045],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005518787,"threshold_uncertainty_score":0.01846218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1367854921733183,"score_gpt":0.4070675391148329,"score_spread":0.2702820469415146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}