{"id":"W3006134978","doi":"10.1016/j.celrep.2020.01.032","title":"B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer’s Patches","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Rising Tide Foundation; Azrieli Foundation; Irma und Jacques Ber-Lehmsdorf - Stiftung; Israel Science Foundation; European Research Council; Human Frontier Science Program; Biotechnology and Biological Sciences Research Council; Gerald O. Mann Charitable Foundation; European Molecular Biology Organization","keywords":"Germinal center; Biology; BCL6; Peyer's patch; Spleen; B cell; Lymphatic system; Plasma cell; Antibody; Immunology; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001366493,0.0002492995,0.0002892102,0.0002463787,0.0001198448,0.0002664172,0.0001635991,0.0002313233,0.0009219614],"category_scores_gemma":[0.0001859117,0.000194036,0.000153874,0.0001106179,0.0003391328,0.000190442,0.0002764495,0.0006590158,0.0002255073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000123394,"about_ca_system_score_gemma":0.0001208474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000215744,"about_ca_topic_score_gemma":0.0003536794,"domain_scores_codex":[0.9998674,0.00002042048,0.00001187675,0.00002849072,0.00002701621,0.00004468997],"domain_scores_gemma":[0.9995897,0.00006552174,0.0001089877,0.00004145252,0.00002016546,0.0001740991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001151817,0.00001151696,0.0007056888,0.00001441064,0.00000348132,0.0000814976,0.000007060187,0.00001254334,0.9985469,0.00003502665,0.00001035291,0.0004562546],"study_design_scores_gemma":[0.00009327988,0.0008275607,0.1289737,0.00001508155,0.000052063,0.003309223,0.00006553478,0.0009617039,0.863844,0.0002088204,0.001641269,0.000007763696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988731,0.0002717376,0.0004584009,0.00001538556,0.000003051631,0.000003198982,0.00003682699,0.00002491164,0.0003134533],"genre_scores_gemma":[0.9987179,0.0001481368,0.0005116032,0.00001943836,0.000007113793,0.00000631713,0.0001078678,0.00001337617,0.0004682139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009219614,"threshold_uncertainty_score":0.003084302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0127073645451523,"score_gpt":0.2068929857987936,"score_spread":0.1941856212536413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}