{"id":"W3006134978","doi":"10.1016/j.celrep.2020.01.032","title":"B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer’s Patches","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Rising Tide Foundation; Azrieli Foundation; Irma und Jacques Ber-Lehmsdorf - Stiftung; Israel Science Foundation; European Research Council; Human Frontier Science Program; Biotechnology and Biological Sciences Research Council; Gerald O. Mann Charitable Foundation; European Molecular Biology Organization","keywords":"Germinal center; Biology; BCL6; Peyer's patch; Spleen; B cell; Lymphatic system; Plasma cell; Antibody; Immunology; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000159221,0.0002713168,0.0003725133,0.0001084879,0.0001607812,0.00002115163,0.0001793064,0.0004260289,0.001591467],"category_scores_gemma":[0.00004170573,0.0002642068,0.000114196,0.0002690072,0.0001530599,0.0001364714,0.00009758713,0.000493045,0.00049339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002192257,"about_ca_system_score_gemma":0.0002352353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001964289,"about_ca_topic_score_gemma":0.0001767829,"domain_scores_codex":[0.9980249,0.0001366624,0.0006530552,0.0006927755,0.00006101488,0.0004315845],"domain_scores_gemma":[0.998975,0.00009299707,0.0005377007,0.0002775887,0.00006562075,0.00005105541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001618204,0.000134731,0.03135912,0.00003814687,0.00004975123,0.0001298898,0.002956823,0.00005812426,0.9588279,0.00000150207,0.006115487,0.000166666],"study_design_scores_gemma":[0.001430278,0.0003143486,0.003579563,0.00002469058,0.00007395421,0.00004593146,0.001099417,0.0002561065,0.9771885,0.00004531446,0.01562689,0.0003149999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941889,0.003116126,0.00007923289,0.0003430549,0.0008961156,0.0003256483,0.00002156703,0.0001153087,0.0009140258],"genre_scores_gemma":[0.9964268,0.0002281111,0.00004188268,0.0003235778,0.00007371679,0.00002206945,0.0009547172,0.0000249939,0.001904091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02777956,"threshold_uncertainty_score":0.999981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0127073645451523,"score_gpt":0.2068929857987936,"score_spread":0.1941856212536413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}