{"id":"W3006135268","doi":"10.1097/cce.0000000000000083","title":"Importance of Endotoxin Clearance in Endotoxemic Septic Shock: An Analysis From the Evaluating Use of PolymyxinB Hemoperfusion in a Randomized Controlled Trial of Adults Treated for Endotoxemic Septic Shock (EUPHRATES) Trial","year":2020,"lang":"en","type":"article","venue":"Critical Care Explorations","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Tornado Spectral Systems (Canada)","funders":"","keywords":"Hemoperfusion; Septic shock; Medicine; Polymyxin B; Randomized controlled trial; Polymyxin; Mechanical ventilation; Shock (circulatory); Internal medicine; Anesthesia; Sepsis; Antibiotics; Biology; Hemodialysis; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.001227993,0.0002694474,0.002172859,0.0003050309,0.0001041218,0.00002195358,0.0002667023,0.0002547681,0.0001592748],"category_scores_gemma":[0.01558193,0.0002030272,0.0007557489,0.0007619276,0.0003624325,0.0003768088,0.00005048813,0.0002967286,0.000004278831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006867721,"about_ca_system_score_gemma":0.0002838551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004628238,"about_ca_topic_score_gemma":0.0006196715,"domain_scores_codex":[0.9938791,0.002903046,0.002309417,0.0004333192,0.0001549438,0.0003201217],"domain_scores_gemma":[0.9897033,0.008763574,0.0005358616,0.0004383495,0.0005207313,0.00003818499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6741269,0.0002321831,0.0002874384,0.00004044905,0.0002507071,0.000001411,0.005338827,0.0006096927,0.3186968,0.0002016237,0.00000555522,0.0002084044],"study_design_scores_gemma":[0.8169683,0.001794957,0.0002139836,0.0001506882,0.001241453,6.872713e-7,0.004740702,0.01867294,0.1559518,0.00008615973,0.00000352501,0.0001748072],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898221,0.001313726,0.0009172512,0.0003873514,0.0001720874,0.007159265,0.000186119,0.00002447205,0.00001763447],"genre_scores_gemma":[0.9968694,0.0000743049,0.0002470739,0.00007582659,0.00005880971,0.001858358,0.0007815607,0.00002227927,0.00001239164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.162745,"threshold_uncertainty_score":0.9927102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0505312521980987,"score_gpt":0.3290081359144123,"score_spread":0.2784768837163136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}