{"id":"W3006135268","doi":"10.1097/cce.0000000000000083","title":"Importance of Endotoxin Clearance in Endotoxemic Septic Shock: An Analysis From the Evaluating Use of PolymyxinB Hemoperfusion in a Randomized Controlled Trial of Adults Treated for Endotoxemic Septic Shock (EUPHRATES) Trial","year":2020,"lang":"en","type":"article","venue":"Critical Care Explorations","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Tornado Spectral Systems (Canada)","funders":"","keywords":"Hemoperfusion; Septic shock; Medicine; Polymyxin B; Randomized controlled trial; Polymyxin; Mechanical ventilation; Shock (circulatory); Internal medicine; Anesthesia; Sepsis; Antibiotics; Biology; Hemodialysis; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0075029,0.001242866,0.003350361,0.0003062212,0.0002634409,0.001165068,0.0006580346,0.001251835,0.002815353],"category_scores_gemma":[0.009470169,0.0004187118,0.004083816,0.00034603,0.0008523153,0.0007063895,0.0004677098,0.002133377,0.0001862146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005719351,"about_ca_system_score_gemma":0.0009043124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007217818,"about_ca_topic_score_gemma":0.001226521,"domain_scores_codex":[0.9930032,0.005775147,0.0003837332,0.0003583373,0.0002470023,0.0002324891],"domain_scores_gemma":[0.9921439,0.004383701,0.002002033,0.0004558749,0.0002719035,0.0007426686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9810035,0.000997141,0.003869685,0.0007467376,0.004974633,0.0000376036,0.00003063139,0.0003056383,0.0008214146,0.00008274832,0.0003324656,0.006797844],"study_design_scores_gemma":[0.94214,0.03683035,0.01239713,0.0001091342,0.006532566,0.00004634569,0.00002996723,0.001044402,0.000356022,0.0001356645,0.0003576002,0.00002084582],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863354,0.009396117,0.0007622785,0.0008462588,0.0002773097,0.001170736,0.0005107118,0.00003732484,0.0006638036],"genre_scores_gemma":[0.9943245,0.002249677,0.0008100105,0.0005391971,0.0002997306,0.0009049377,0.0004692179,0.00001024366,0.0003924791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0075029,"threshold_uncertainty_score":0.03967959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0505312521980987,"score_gpt":0.3290081359144123,"score_spread":0.2784768837163136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}