{"id":"W3006145067","doi":"10.1038/s41598-019-57153-9","title":"Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Cancer Research UK","keywords":"Endosome; Endocytosis; Cell biology; Cancer research; Ubiquitin; Epidermal growth factor receptor; Chemistry; Internalization; Receptor; Biology; Intracellular; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002136552,0.0003716794,0.000272515,0.0002063479,0.00008735885,0.0002669694,0.0002438524,0.0003307276,0.0009488545],"category_scores_gemma":[0.0001715568,0.0001565901,0.0002343156,0.0001264249,0.0001583362,0.0002210534,0.0002081316,0.0003482719,0.0002912673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000376714,"about_ca_system_score_gemma":0.0001657986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002903285,"about_ca_topic_score_gemma":0.0009827118,"domain_scores_codex":[0.9997813,0.00005484287,0.0000150595,0.00003147721,0.00006592992,0.00005142556],"domain_scores_gemma":[0.9999173,0.00002242255,0.00001919861,0.000014226,0.00001268394,0.00001421881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008497656,0.00002960247,0.0001349167,0.00002162599,0.000006314569,0.00003882323,0.000005496242,0.00008973687,0.9977419,0.00006558193,0.00002845658,0.001752614],"study_design_scores_gemma":[0.00002400502,0.0008066013,0.001747127,0.000002037955,0.00001284661,0.0002407198,0.000005627168,0.0007684362,0.9949182,0.00002286189,0.001448395,0.000003306452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949181,0.0006647423,0.003149723,0.00004843685,0.0000111537,0.00003598759,0.00005301271,0.00004998565,0.001068819],"genre_scores_gemma":[0.9946115,0.0004794733,0.003189649,0.0000352961,0.000008135493,0.00003751517,0.0001068391,0.00001313538,0.001518336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009488545,"threshold_uncertainty_score":0.003174186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009640638469152583,"score_gpt":0.2188634549552349,"score_spread":0.2092228164860823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}