{"id":"W3006171833","doi":"10.1101/2020.01.24.20018713","title":"Lab-wide association scan of polygenic scores identifies biomarkers of complex disease","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Georgia Clinical and Translational Science Alliance; National Institutes of Health; Vanderbilt University Medical Center; Vanderbilt University; National Institute of General Medical Sciences; American Heart Association","keywords":"Biobank; Coronary artery disease; Disease; Association test; Medicine; Heritability; Biomarker; Bioinformatics; Internal medicine; Biology; Genetics; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006007823,0.0006268262,0.0007440296,0.002356044,0.000411106,0.001675918,0.0006943154,0.000731427,0.005152278],"category_scores_gemma":[0.01963079,0.0003162207,0.001180547,0.002264521,0.0007520961,0.0004436111,0.001279196,0.001015086,0.0006561477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002967358,"about_ca_system_score_gemma":0.0006136266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002125902,"about_ca_topic_score_gemma":0.001822065,"domain_scores_codex":[0.9956338,0.002467703,0.000189037,0.001103792,0.0004062109,0.0001994556],"domain_scores_gemma":[0.9788537,0.01470496,0.002751913,0.002536807,0.0005986677,0.0005540947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001460887,0.0002293776,0.9215169,0.0002788132,0.00418633,0.0009220675,0.0002750957,0.006911014,0.0177481,0.004197222,0.005016025,0.03725814],"study_design_scores_gemma":[0.0004134229,0.0004797848,0.8971083,0.00009283073,0.001992259,0.001974507,0.0002208516,0.06048993,0.008627895,0.02098935,0.007514372,0.00009646362],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8841928,0.001309004,0.09713328,0.001598539,0.0001277986,0.00007397118,0.01175508,0.001359879,0.002449799],"genre_scores_gemma":[0.9754087,0.0002531082,0.01921057,0.0003478634,0.0001008016,0.00007205606,0.003827812,0.0001201908,0.0006588879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006007823,"threshold_uncertainty_score":0.03177279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02697499889501835,"score_gpt":0.2837346508935154,"score_spread":0.256759651998497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}