{"id":"W3006188747","doi":"10.1158/1538-7445.sabcs19-p3-10-07","title":"Abstract P3-10-07: Receptor-mediated chemotherapy using a new Docetaxel-peptide conjugate for Sortilin-positive triple-negative breast cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Theratechnologies (Canada)","funders":"","keywords":"Internalization; Cancer research; Docetaxel; Flow cytometry; Triple-negative breast cancer; Cancer; Breast cancer; Nude mouse; Clonogenic assay; Biology; Conjugate; Cancer cell; Paclitaxel; In vitro; Peptide; Molecular biology; Cell; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000766743,0.0002952379,0.0001797866,0.0001617841,0.00008786145,0.0001778928,0.0001962936,0.0002402444,0.0008200759],"category_scores_gemma":[0.00004902113,0.0001153627,0.00015878,0.0001243072,0.0001172633,0.0001248911,0.0001235752,0.0002594688,0.0004303614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002877761,"about_ca_system_score_gemma":0.0002305986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005109296,"about_ca_topic_score_gemma":0.0005908618,"domain_scores_codex":[0.9999471,0.000006746362,0.000003673027,0.00001319987,0.00001642868,0.00001281521],"domain_scores_gemma":[0.9999801,0.000001831028,0.000004685584,0.000001729942,0.00000342216,0.000008185977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001573023,0.00009480129,0.0001323066,0.00006339705,0.000008267748,0.0001123138,0.00001070706,0.0002410375,0.9928537,0.0001217191,0.0002833095,0.005921118],"study_design_scores_gemma":[0.000110313,0.001461068,0.001829347,0.00000633719,0.00002873008,0.0007685919,0.000005787409,0.002243106,0.9882321,0.00002800861,0.005277151,0.000009523489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987726,0.002438867,0.005798512,0.0001420471,0.00005810529,0.0001755266,0.0002447087,0.0001432538,0.003272943],"genre_scores_gemma":[0.9894643,0.001141941,0.005608907,0.00008752967,0.00001251967,0.00008673263,0.0003375477,0.00002160433,0.003238929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008200759,"threshold_uncertainty_score":0.002743423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07602323043770456,"score_gpt":0.4075373612568728,"score_spread":0.3315141308191683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}