{"id":"W3006191171","doi":"10.7150/thno.41219","title":"ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma","year":2020,"lang":"en","type":"article","venue":"Theranostics","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"ATRX; Glioma; Cancer research; Temozolomide; Biology; PARP1; DNA methylation; Genetics; Gene expression; Poly ADP ribose polymerase; Gene; Mutation; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002966489,0.0002478718,0.0005278061,0.00009045505,0.00006975586,0.0000321809,0.0001997884,0.0001265726,0.0002251778],"category_scores_gemma":[0.0006170905,0.0002457111,0.00008571871,0.0006390255,0.000122988,0.00003665369,0.00006797149,0.0002579289,0.0001060406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001673125,"about_ca_system_score_gemma":0.0001200341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001345775,"about_ca_topic_score_gemma":0.00004462384,"domain_scores_codex":[0.9978546,0.0001090895,0.0005813134,0.0004238931,0.0004039207,0.0006272093],"domain_scores_gemma":[0.9985931,0.0003495511,0.0001054863,0.0003777112,0.0002118068,0.0003623803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003810022,0.0001834136,0.01314372,0.0001847627,0.0001259117,0.0003717972,0.003258564,0.0002978904,0.9600928,0.005207869,0.01077102,0.002552223],"study_design_scores_gemma":[0.01755889,0.001842045,0.2114903,0.001486818,0.0001767651,0.0000612353,0.0005730651,0.001770796,0.5193717,0.007553552,0.2367481,0.001366683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9377537,0.002411518,0.01284093,0.04171036,0.0002024234,0.001199202,0.0001155288,0.0006167098,0.003149593],"genre_scores_gemma":[0.9788403,0.0001029406,0.009758517,0.01053716,0.0004727925,0.00002943557,0.00003564796,0.0001081327,0.0001150811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4407211,"threshold_uncertainty_score":0.9999995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04874761959183217,"score_gpt":0.3155345455991141,"score_spread":0.266786926007282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}