{"id":"W3006233208","doi":"10.1182/bloodadvances.2019000525","title":"Tisagenlecleucel cellular kinetics, dose, and immunogenicity in relation to clinical factors in relapsed/refractory DLBCL","year":2020,"lang":"en","type":"article","venue":"Blood Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Hospital","funders":"Legend Biotech; Novartis Pharmaceuticals Corporation","keywords":"Cytokine release syndrome; Immunogenicity; Immunology; Medicine; CD19; Hazard ratio; Internal medicine; Tocilizumab; Oncology; Biology; Immunotherapy; Flow cytometry; Cancer; Antibody; Confidence interval; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006470726,0.0001410205,0.0003515637,0.0002121514,0.00009194233,0.0003872577,0.0001490454,0.0001854162,0.0003813021],"category_scores_gemma":[0.0008998485,0.0001096548,0.0001889394,0.0002031242,0.0001624367,0.0001947025,0.0001861425,0.0002991003,0.0001127573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004295153,"about_ca_system_score_gemma":0.0001426508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004878374,"about_ca_topic_score_gemma":0.000649549,"domain_scores_codex":[0.9997446,0.00009936193,0.00002356223,0.00004743012,0.00005344514,0.00003159961],"domain_scores_gemma":[0.9992362,0.0002260687,0.000322127,0.00005304812,0.00005525409,0.0001072693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02062474,0.0007005124,0.8352957,0.0001349171,0.0002878523,0.0005353774,0.0002137247,0.00223627,0.07753105,0.00006604046,0.0002671773,0.06210677],"study_design_scores_gemma":[0.0004875298,0.01635307,0.9664915,0.000009593711,0.0001916928,0.001221342,0.0001266944,0.00368258,0.01006931,0.00005981757,0.001293028,0.0000138138],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995297,0.0002610829,0.00006131792,0.000007947954,6.230183e-7,0.000007169772,0.00003006391,0.000004607567,0.00009742306],"genre_scores_gemma":[0.9996285,0.00006230544,0.00008548253,0.00001879456,0.000002567335,0.000007759271,0.0001030827,0.000002406357,0.00008906281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006470726,"threshold_uncertainty_score":0.003422081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0500624111526647,"score_gpt":0.3459240145316899,"score_spread":0.2958616033790252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}