{"id":"W3006233208","doi":"10.1182/bloodadvances.2019000525","title":"Tisagenlecleucel cellular kinetics, dose, and immunogenicity in relation to clinical factors in relapsed/refractory DLBCL","year":2020,"lang":"en","type":"article","venue":"Blood Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Hospital","funders":"Legend Biotech; Novartis Pharmaceuticals Corporation","keywords":"Cytokine release syndrome; Immunogenicity; Immunology; Medicine; CD19; Hazard ratio; Internal medicine; Tocilizumab; Oncology; Biology; Immunotherapy; Flow cytometry; Cancer; Antibody; Confidence interval; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003746534,0.0001672844,0.0004161303,0.0001453274,0.00002668359,0.00001767875,0.0001219391,0.0001481467,0.0002518478],"category_scores_gemma":[0.0007239014,0.0001555582,0.00007587279,0.0004530547,0.00009309215,0.0001196574,0.00009282659,0.0005807648,0.00002909013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005216147,"about_ca_system_score_gemma":0.00006034854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007939509,"about_ca_topic_score_gemma":0.000141152,"domain_scores_codex":[0.9981771,0.0001591547,0.0005738501,0.000461602,0.0003228518,0.0003054246],"domain_scores_gemma":[0.9990757,0.0002896359,0.00007724372,0.0002415223,0.0000469105,0.0002690105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006987373,0.0005586881,0.6938382,0.00006064247,0.00002932985,0.0001005795,0.0009171981,0.00003043992,0.2885427,0.00001055707,0.00002587438,0.015187],"study_design_scores_gemma":[0.006247113,0.001583162,0.9286353,0.00009639604,0.0000346689,0.000004458805,0.0002913046,0.0001065733,0.03796007,0.00007460302,0.02476414,0.0002021956],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924583,0.004899353,0.00002751218,0.0009616996,0.0001271362,0.0005852105,0.000006401986,0.00003733747,0.0008969781],"genre_scores_gemma":[0.9969556,0.001352627,0.0006851685,0.0003763983,0.0001787822,0.00001238716,0.00001747371,0.00003028343,0.0003912172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2505827,"threshold_uncertainty_score":0.6343479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0500624111526647,"score_gpt":0.3459240145316899,"score_spread":0.2958616033790252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}