{"id":"W3006237179","doi":"10.1016/j.bbalip.2020.158660","title":"The role of the C-terminal domain of PCSK9 and SEC24 isoforms in PCSK9 secretion","year":2020,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"PCSK9; Secretion; Kexin; Mutant; LDL receptor; Proprotein convertase; Subtilisin; Biology; Mutant protein; Amino acid; Cell biology; Biochemistry; Lipoprotein; Cholesterol; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002796236,0.0003139389,0.0002297221,0.0002298518,0.0002672804,0.0006138029,0.0002340276,0.0003909317,0.001122497],"category_scores_gemma":[0.0003150642,0.0001737099,0.0004335465,0.0001601833,0.000351329,0.0006577728,0.00035056,0.0004821748,0.0005522112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004346504,"about_ca_system_score_gemma":0.0003274628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005387297,"about_ca_topic_score_gemma":0.0004153281,"domain_scores_codex":[0.9998666,0.0000252274,0.00002336623,0.00002866387,0.00002283141,0.00003324753],"domain_scores_gemma":[0.9997084,0.00004434545,0.00007282262,0.00004195597,0.00003958418,0.00009291204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001546073,0.00002641724,0.003432375,0.00004523671,0.00002328735,0.0004486908,0.00003585224,0.0002366675,0.9901692,0.0006996724,0.00007494759,0.003261773],"study_design_scores_gemma":[0.0001058448,0.0002420643,0.06795333,0.00002301206,0.00005129959,0.002655243,0.0002042271,0.003777817,0.9187647,0.0007703902,0.005419119,0.00003302947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944818,0.003102156,0.00125743,0.0001560453,0.00002505453,0.000006801527,0.0001669198,0.00001607929,0.0007878],"genre_scores_gemma":[0.9956813,0.0008586619,0.0009112313,0.00003328155,0.00000949614,0.000005940764,0.0002872747,0.00001324801,0.002199644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001122497,"threshold_uncertainty_score":0.003755152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004102799760687826,"score_gpt":0.1976744987202675,"score_spread":0.1935716989595797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}