{"id":"W3006243314","doi":"10.1101/2020.02.12.942755","title":"Human papillomavirus integration transforms chromatin to drive oncogenesis","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vector Institute; Princess Margaret Cancer Centre; University of Toronto","funders":"Peterborough K. M. Hunter Charitable Foundation; University of Toronto; Princess Margaret Cancer Foundation","keywords":"CTCF; Chromatin; Biology; Epigenome; Carcinogenesis; Gene; Genome; Lytic cycle; Genetics; Transcription factor; Cancer research; Gene expression; Virus; DNA methylation; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001525167,0.000159934,0.0001092018,0.0001881017,0.0001147638,0.0003424325,0.0001213908,0.0001464321,0.002112378],"category_scores_gemma":[0.0001307934,0.0001376872,0.0002004786,0.0001661691,0.0001820409,0.0001497784,0.0002910236,0.0003545031,0.0003442818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002943487,"about_ca_system_score_gemma":0.0001197885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006605457,"about_ca_topic_score_gemma":0.000796525,"domain_scores_codex":[0.9998962,0.00001240586,0.000005888754,0.00003485458,0.00003022232,0.00002047221],"domain_scores_gemma":[0.999902,0.00002513689,0.00002312581,0.0000192203,0.00001017759,0.00002034147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001893403,0.000009015654,0.0005124239,0.00001914274,0.000003729687,0.00001543181,0.000009985835,0.00004227694,0.9980568,0.0001398107,0.00004345703,0.001128967],"study_design_scores_gemma":[0.00001039884,0.0001304708,0.02370009,0.00001055063,0.00001778583,0.0002014426,0.00003847977,0.002002479,0.9668688,0.0003381926,0.006675025,0.000006298465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831261,0.002020535,0.01099884,0.0001021187,0.00006831171,0.0000346867,0.0008205285,0.0002561752,0.00257263],"genre_scores_gemma":[0.9951369,0.0004054673,0.002139212,0.00004976635,0.000006809013,0.0000126292,0.0006450069,0.00003555376,0.001568669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002112378,"threshold_uncertainty_score":0.007066667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03694373121846221,"score_gpt":0.3037673472114445,"score_spread":0.2668236159929823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}