{"id":"W3006253646","doi":"10.7150/thno.42611","title":"Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal Müller glia","year":2020,"lang":"en","type":"article","venue":"Theranostics","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Gene delivery; mCherry; Muller glia; Retinal; Green fluorescent protein; Retina; Biology; Transduction (biophysics); Reporter gene; Ex vivo; Cell biology; Microbubbles; Genetic enhancement; Viral vector; In vivo; Stem cell; Progenitor cell; Recombinant DNA; Neuroscience; Gene expression; Medicine; Gene; Ultrasound; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002731028,0.0004584604,0.00024125,0.0003008945,0.0002310004,0.0004165735,0.000342986,0.0007124477,0.0009524684],"category_scores_gemma":[0.0002065304,0.0001984724,0.0002323634,0.0001610199,0.0005360434,0.0005363364,0.0004757441,0.0005900054,0.0003744306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004512674,"about_ca_system_score_gemma":0.000363513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001027028,"about_ca_topic_score_gemma":0.001611582,"domain_scores_codex":[0.9998379,0.00002645816,0.000008438701,0.00004066097,0.00005744761,0.00002904171],"domain_scores_gemma":[0.9999008,0.0000319245,0.00002658189,0.000008375875,0.0000144522,0.00001782431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002319455,0.000009724958,0.0000256985,0.00005918351,0.000003076275,0.00007614453,0.00004243124,0.00006964317,0.9953507,0.000471472,0.00009918484,0.003769595],"study_design_scores_gemma":[0.00001667732,0.0004266062,0.000416124,0.00001675535,0.00001780313,0.0005310023,0.00003760317,0.001363933,0.9901244,0.0002433489,0.006788531,0.00001734083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6552482,0.02212125,0.3075237,0.002481356,0.0005205674,0.0003056667,0.0002323303,0.001085439,0.01048168],"genre_scores_gemma":[0.9053054,0.009401556,0.07591346,0.0006665125,0.0001201356,0.0002120978,0.0001296615,0.00009236857,0.008158864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001027028,"threshold_uncertainty_score":0.003274202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0264804965720937,"score_gpt":0.2562825687887633,"score_spread":0.2298020722166696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}