{"id":"W3006253646","doi":"10.7150/thno.42611","title":"Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal Müller glia","year":2020,"lang":"en","type":"article","venue":"Theranostics","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Gene delivery; mCherry; Muller glia; Retinal; Green fluorescent protein; Retina; Biology; Transduction (biophysics); Reporter gene; Ex vivo; Cell biology; Microbubbles; Genetic enhancement; Viral vector; In vivo; Stem cell; Progenitor cell; Recombinant DNA; Neuroscience; Gene expression; Medicine; Gene; Ultrasound; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005402126,0.0001841703,0.0001462748,0.00001901859,0.00005545033,0.00003794148,0.0002007936,0.0001167457,0.00002396389],"category_scores_gemma":[0.0003228959,0.0001781335,0.00008509693,0.00008805569,0.00004050004,0.000002904188,0.00004832859,0.00005930508,0.00003419868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009183449,"about_ca_system_score_gemma":0.0001594973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001078599,"about_ca_topic_score_gemma":0.0000110602,"domain_scores_codex":[0.9990638,0.00001606551,0.0001823628,0.0003323864,0.0001276875,0.0002776621],"domain_scores_gemma":[0.999419,0.00005138182,0.00005119964,0.0001558366,0.0001495416,0.0001730669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009423801,0.00004419777,0.0004372855,0.00002002623,0.00006989064,0.000004362012,0.0004011536,0.0002834495,0.991765,0.000223525,0.005131508,0.0006772185],"study_design_scores_gemma":[0.002894968,0.002640404,0.002111695,0.00002260004,0.00007450117,0.00002280778,0.0005446242,0.0001026309,0.9028866,0.0004333681,0.08757522,0.0006905635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689087,0.0004046868,0.02795013,0.0008038121,0.0001105984,0.0005413772,0.00005972495,0.00005416066,0.001166847],"genre_scores_gemma":[0.985958,0.0001419392,0.009129331,0.003870793,0.0002908481,0.00003526557,0.0001648776,0.00007408969,0.0003348439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08887839,"threshold_uncertainty_score":0.7264073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0264804965720937,"score_gpt":0.2562825687887633,"score_spread":0.2298020722166696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}