{"id":"W3006253655","doi":"10.3390/ijms21041309","title":"Mdm2 and MdmX RING Domains Play Distinct Roles in the Regulation of p53 Responses: A Comparative Study of Mdm2 and MdmX RING Domains in U2OS Cells","year":2020,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada; Leukemia and Lymphoma Society of Canada; Leukemia and Lymphoma Society","keywords":"MDMX; Mdm2; Ubiquitin ligase; Transactivation; Ubiquitin; Cell biology; Biology; Gene; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008469087,0.0002008044,0.0002391044,0.0003036055,0.0001730308,0.0002426503,0.0001053121,0.0001920207,0.0005442854],"category_scores_gemma":[0.00005547845,0.0000950291,0.0002446595,0.0002685468,0.0001287409,0.0002542788,0.0001078841,0.0001476646,0.0001671597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001173878,"about_ca_system_score_gemma":0.0000656197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004780876,"about_ca_topic_score_gemma":0.0003608099,"domain_scores_codex":[0.9999318,0.00001059462,0.000005839893,0.00001471558,0.00001830525,0.00001863221],"domain_scores_gemma":[0.9999622,0.000008877723,0.000006884108,0.000004342978,0.000005723499,0.00001192364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001697638,0.0000165097,0.0006401618,0.00002191594,0.000004380623,0.0001241798,0.00002542512,0.00002941815,0.9979767,0.00007118687,0.00001345494,0.0009068453],"study_design_scores_gemma":[0.00002090719,0.0006071734,0.06477645,0.000007063177,0.00004864607,0.001566267,0.0002780738,0.001518997,0.9258188,0.000117109,0.005228317,0.0000122312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944336,0.003616778,0.0008218492,0.0000265624,0.000009664154,0.000007961679,0.0002302634,0.00001605992,0.0008372511],"genre_scores_gemma":[0.9963384,0.001599199,0.0005817306,0.00002313455,0.000008043634,0.00001348474,0.0003781444,0.00000475558,0.001053093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005442854,"threshold_uncertainty_score":0.001820803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03224921526535483,"score_gpt":0.323368394459755,"score_spread":0.2911191791944001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}