{"id":"W3006385260","doi":"10.1128/jvi.01845-19","title":"Integrated Assessment of Viral Transcription, Antigen Presentation, and CD8<sup>+</sup>T Cell Function Reveals Multiple Limitations of Class I-Selective Histone Deacetylase Inhibitors during HIV-1 Latency Reversal","year":2020,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Maple Leaf Medical Clinic","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Biology; Histone deacetylase; Clinical trial; Immunology; HDAC1; Immune system; Bioinformatics; Histone; Virology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005694434,0.0003388508,0.0003241384,0.0002457146,0.0001767177,0.0008057253,0.0002343978,0.000429211,0.001270369],"category_scores_gemma":[0.0003277155,0.0001529362,0.0001726901,0.0001631948,0.0004329791,0.0004461443,0.0001978391,0.001010562,0.0003717696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003718166,"about_ca_system_score_gemma":0.0002864818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003891968,"about_ca_topic_score_gemma":0.0007169207,"domain_scores_codex":[0.9996855,0.00009588991,0.0000179967,0.00005598984,0.00007195624,0.00007265677],"domain_scores_gemma":[0.9998896,0.00003140629,0.00001892609,0.00001956082,0.00001921647,0.00002122803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007226191,0.0001205183,0.00191268,0.00006414556,0.000007359437,0.00002465748,0.00003324105,0.0001965031,0.9827372,0.0003647344,0.0001096565,0.01370664],"study_design_scores_gemma":[0.00005103836,0.00207969,0.02041739,0.00002684833,0.00004187049,0.0002578918,0.0001807234,0.007245969,0.9664363,0.0006762726,0.002575944,0.00001018571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808484,0.004965447,0.01005001,0.000247514,0.00004878731,0.00005939061,0.0003137496,0.0001438305,0.003322922],"genre_scores_gemma":[0.9928048,0.001393657,0.004075774,0.00009743591,0.00002102779,0.00004457956,0.0001849861,0.00001501364,0.001362726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001270369,"threshold_uncertainty_score":0.004249871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02423098243946889,"score_gpt":0.2662158456604359,"score_spread":0.241984863220967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}