{"id":"W3006385761","doi":"10.1002/jcph.1575","title":"Pharmacokinetics, Safety, and Tolerability of Orally Administered Ursodeoxycholic Acid in Patients With Parkinson's Disease—A Pilot Study","year":2020,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institutes of Health","keywords":"Tolerability; Ursodeoxycholic acid; Medicine; Pharmacokinetics; Internal medicine; Parkinson's disease; Gastroenterology; Adverse effect; Pharmacology; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006385192,0.0006483807,0.001222403,0.0002318833,0.0003383118,0.0004341961,0.0002231092,0.0005211348,0.000888421],"category_scores_gemma":[0.001056878,0.0002800176,0.0006209476,0.0002390328,0.0004499011,0.0004352412,0.0001728461,0.0009889483,0.0002472548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002634718,"about_ca_system_score_gemma":0.0003494716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004723404,"about_ca_topic_score_gemma":0.0005029037,"domain_scores_codex":[0.9997348,0.0001218441,0.00002199471,0.00005455967,0.00003715792,0.00002948529],"domain_scores_gemma":[0.9993561,0.000166584,0.0001397902,0.00007064456,0.00006108369,0.0002058465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4417202,0.02855803,0.1161663,0.0005911799,0.001652407,0.001835917,0.001079609,0.002588886,0.2571847,0.0001200722,0.00121048,0.1472923],"study_design_scores_gemma":[0.03179123,0.7409048,0.2030456,0.00003164752,0.0008551904,0.001307726,0.0002127491,0.002540405,0.016919,0.00009096853,0.002251934,0.00004872158],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988737,0.0004306182,0.000224774,0.00002534842,0.000008447109,0.00011341,0.0001283964,0.0000208156,0.000174594],"genre_scores_gemma":[0.9988284,0.0001835072,0.0003584045,0.00005767343,0.00002585312,0.0001028932,0.0002176571,0.000006639795,0.0002191237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001222403,"threshold_uncertainty_score":0.003376842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05089371776168045,"score_gpt":0.3615983000893986,"score_spread":0.3107045823277182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}