{"id":"W3006399675","doi":"10.1093/biomethods/bpaa003","title":"Genome editing in the nematode Caenorhabditis briggsae using the CRISPR/Cas9 system","year":2020,"lang":"en","type":"article","venue":"Biology Methods and Protocols","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"CRISPR; Cas9; Biology; Genetics; Genome editing; Gene; Plasmid; Caenorhabditis elegans; Genome; Caenorhabditis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003103018,0.000344989,0.0001862053,0.0004022539,0.0003017687,0.0003214191,0.0003635059,0.0003969977,0.000852873],"category_scores_gemma":[0.000181048,0.0001864381,0.0002513066,0.0001198795,0.0003538152,0.000168239,0.0003958043,0.0005428585,0.0003566468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003301666,"about_ca_system_score_gemma":0.0002767863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002245937,"about_ca_topic_score_gemma":0.003772681,"domain_scores_codex":[0.9998096,0.0000261254,0.00002553294,0.00005057016,0.00006564525,0.00002255777],"domain_scores_gemma":[0.9998851,0.00002628239,0.00003575806,0.00002453794,0.0000104721,0.00001778362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001344518,0.000008187545,0.00005416756,0.00002183749,0.000002834542,0.00004467957,0.000006554422,0.00008660748,0.9990295,0.0001068132,0.00002843383,0.0005968061],"study_design_scores_gemma":[0.00001185767,0.00008835441,0.001573753,0.00001164493,0.00001026596,0.0002720999,0.00001502365,0.0007681498,0.9935055,0.0000530376,0.003678467,0.000011803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9552715,0.002435411,0.03573931,0.0002550224,0.0001174655,0.0002231786,0.001048607,0.0006665642,0.004242819],"genre_scores_gemma":[0.950855,0.001300389,0.04140195,0.00009457361,0.000007472528,0.00009085865,0.0007160627,0.00009494303,0.005438851],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002245937,"threshold_uncertainty_score":0.004465759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05870226766973503,"score_gpt":0.4578715914963711,"score_spread":0.3991693238266361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}