{"id":"W3006399675","doi":"10.1093/biomethods/bpaa003","title":"Genome editing in the nematode Caenorhabditis briggsae using the CRISPR/Cas9 system","year":2020,"lang":"en","type":"article","venue":"Biology Methods and Protocols","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"CRISPR; Cas9; Biology; Genetics; Genome editing; Gene; Plasmid; Caenorhabditis elegans; Genome; Caenorhabditis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001185364,0.0001558224,0.0002000882,0.00001877893,0.0001409407,0.00003879032,0.0002705254,0.0001510809,0.000004932971],"category_scores_gemma":[0.0001597923,0.00009402503,0.00005946017,0.0001131467,0.00009097659,0.000002511736,0.0001268951,0.000166752,9.612372e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006939876,"about_ca_system_score_gemma":0.00002917898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003867785,"about_ca_topic_score_gemma":0.00000826104,"domain_scores_codex":[0.9984766,0.0006527013,0.0002520512,0.0003114077,0.00004915974,0.0002580341],"domain_scores_gemma":[0.9995044,0.00008718429,0.00007431061,0.000252054,0.00002774195,0.00005429497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004187462,0.00001117195,0.002853043,0.0001991211,0.00003532654,0.000007878973,0.0006197235,0.0002482839,0.9873896,0.0005993739,0.00008023047,0.007914376],"study_design_scores_gemma":[0.002527328,0.001562265,0.01998258,0.0002364338,0.0001135545,0.0008087524,0.00610381,0.01187832,0.3575682,0.0004575502,0.5976089,0.001152299],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1760774,0.002962957,0.7849123,0.001712796,0.0002137504,0.03321223,0.00003965971,0.00004442596,0.0008244065],"genre_scores_gemma":[0.917275,0.00004572718,0.06272019,0.001444712,0.001829773,0.01660278,0.00002823891,0.00004039729,0.00001322125],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7411976,"threshold_uncertainty_score":0.3834229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05870226766973503,"score_gpt":0.4578715914963711,"score_spread":0.3991693238266361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}