{"id":"W3006411236","doi":"10.1021/acs.inorgchem.9b03072","title":"Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase","year":2020,"lang":"en","type":"article","venue":"Inorganic Chemistry","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Knut och Alice Wallenbergs Stiftelse; Canada Research Chairs; Cancerfonden; Canada Foundation for Innovation","keywords":"Chemistry; Auranofin; Thioredoxin reductase; Selenocysteine; Methylmercury; Thioredoxin; Biochemistry; Stereochemistry; Cysteine; Enzyme; Selenium; Organic chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001091095,0.0001302974,0.0001883732,0.00001611479,0.00002341831,0.000005935197,0.0001414211,0.0001661421,0.00002811006],"category_scores_gemma":[0.000299297,0.0001301009,0.00003093917,0.0002061943,0.00006212242,0.000004485938,0.0001199435,0.00009269737,0.000002708962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001090101,"about_ca_system_score_gemma":0.00004687022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001256672,"about_ca_topic_score_gemma":0.000004560388,"domain_scores_codex":[0.9991891,0.00003837949,0.0002264076,0.0003420874,0.00005501407,0.000149001],"domain_scores_gemma":[0.9996033,0.00001796041,0.00007602845,0.0001642077,0.00004542368,0.00009313421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009638127,0.00001965448,0.009470359,0.00008901733,0.00002411319,0.000003436277,0.0001916238,0.00000593972,0.9895145,0.00000419452,0.000259659,0.0003211107],"study_design_scores_gemma":[0.0003792418,0.00008489999,0.003156766,0.00002545828,0.000009181266,0.000005528511,0.0001797664,0.000008031263,0.9945872,0.000008764794,0.001418563,0.0001366279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977318,0.0006499166,0.00004521036,0.0005839767,0.00002131305,0.0001031934,0.0000402175,0.000009494182,0.0008148491],"genre_scores_gemma":[0.9989291,0.00008232876,0.0003738461,0.0002308586,0.0001056323,0.000007742236,0.0001317507,0.00001297682,0.0001257675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006313594,"threshold_uncertainty_score":0.5305361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01447929483180469,"score_gpt":0.2451032423467975,"score_spread":0.2306239475149928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}