{"id":"W3006411236","doi":"10.1021/acs.inorgchem.9b03072","title":"Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase","year":2020,"lang":"en","type":"article","venue":"Inorganic Chemistry","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Knut och Alice Wallenbergs Stiftelse; Canada Research Chairs; Cancerfonden; Canada Foundation for Innovation","keywords":"Chemistry; Auranofin; Thioredoxin reductase; Selenocysteine; Methylmercury; Thioredoxin; Biochemistry; Stereochemistry; Cysteine; Enzyme; Selenium; Organic chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000145933,0.0002294713,0.0002315579,0.0001116806,0.0001754681,0.0001399168,0.0003990344,0.0004225759,0.001048078],"category_scores_gemma":[0.0002075858,0.0002089952,0.0003460601,0.0001395943,0.0002824983,0.0001435006,0.0002799239,0.0006603134,0.0002087957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002804988,"about_ca_system_score_gemma":0.0001288231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001140665,"about_ca_topic_score_gemma":0.001209466,"domain_scores_codex":[0.9998665,0.00001782042,0.000005205794,0.00003665584,0.00004490542,0.00002879104],"domain_scores_gemma":[0.9998366,0.00004122516,0.00005305389,0.00002359997,0.00002182135,0.00002371461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008000694,0.00001597929,0.0005313107,0.00002545987,0.00001431193,0.00006837452,0.00002312,0.0001098004,0.9984487,0.00007016821,0.00001721157,0.0005954999],"study_design_scores_gemma":[0.000009487221,0.0001602131,0.006890306,0.000003173339,0.0000132741,0.0002094541,0.00002931403,0.0006094215,0.991456,0.00003350584,0.0005808677,0.000005050508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961976,0.0007274839,0.002006787,0.0000750283,0.000006862869,0.000004702578,0.0000549311,0.00003671102,0.0008898843],"genre_scores_gemma":[0.9972355,0.0002448338,0.001137485,0.00003735048,0.000002158809,0.00000506906,0.0001150044,0.000009556997,0.001213057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001140665,"threshold_uncertainty_score":0.003506184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01447929483180469,"score_gpt":0.2451032423467975,"score_spread":0.2306239475149928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}