{"id":"W3006481764","doi":"10.1074/jbc.ra119.011136","title":"ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1)","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences; Deutsche Forschungsgemeinschaft","keywords":"Rhomboid; Chemistry; Biochemistry; Enzyme; Proteases","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003869609,0.0004246137,0.000613742,0.00002355988,0.0001213213,0.00006122918,0.0006914386,0.0004735622,0.0003709052],"category_scores_gemma":[0.004306939,0.0003312109,0.0004707349,0.0001552689,0.0002387689,0.00002723789,0.0003775007,0.0008377944,0.00002154364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001124626,"about_ca_system_score_gemma":0.0002650861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002042556,"about_ca_topic_score_gemma":2.983303e-7,"domain_scores_codex":[0.9975647,0.0001781074,0.0008223579,0.0005966823,0.0003597962,0.0004782967],"domain_scores_gemma":[0.997497,0.0002359284,0.0008994199,0.0002973217,0.0005169593,0.0005533673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002022079,0.000236696,0.002616694,0.00006890497,0.0002277207,0.0001240304,0.0001499547,0.00008332726,0.9925963,0.000007195247,0.001240219,0.0006268274],"study_design_scores_gemma":[0.001045551,0.0009139651,0.001025082,0.00007035406,0.00007070648,0.0001535383,0.001013959,0.00006131011,0.9896401,0.00004447488,0.005546637,0.0004142989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958319,0.001152373,0.0003756139,0.0008121393,0.0002056721,0.0001504683,0.0000895535,0.00002887815,0.001353407],"genre_scores_gemma":[0.9964835,0.0002154367,0.0005278068,0.001022483,0.001513458,0.00001407828,0.00005499847,0.00003733469,0.0001309134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004306418,"threshold_uncertainty_score":0.999914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05197245163751866,"score_gpt":0.292631356468175,"score_spread":0.2406589048306563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}