{"id":"W3006492270","doi":"10.1101/2020.02.16.951681","title":"Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"FujiFilm VisualSonics (Canada)","funders":"National Cancer Institute; Harvard Catalyst; National Institutes of Health; American Cancer Society","keywords":"Glutamine; Biology; Pancreatic cancer; mTORC1; Cancer research; Glutamine synthetase; Cancer; Cell biology; Biochemistry; Amino acid; Genetics; Signal transduction; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000679858,0.0001630503,0.0002103842,0.0001047961,0.0001720937,0.0003905985,0.0001406981,0.0001463789,0.001076608],"category_scores_gemma":[0.00008787469,0.0000966649,0.0001887058,0.0001463368,0.0001338614,0.0001078258,0.0002970327,0.0003394383,0.0003546251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002170056,"about_ca_system_score_gemma":0.0001782341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004384836,"about_ca_topic_score_gemma":0.0007018604,"domain_scores_codex":[0.9999114,0.000007808359,0.00001009716,0.00002641826,0.00002772478,0.00001641364],"domain_scores_gemma":[0.9999288,0.00001042554,0.00002159402,0.00001327554,0.00001060582,0.0000152218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005095838,0.00001112251,0.0006818475,0.00001957068,0.000004521925,0.0000462726,0.000008027356,0.00005397874,0.9977369,0.00004827915,0.00005660005,0.00128193],"study_design_scores_gemma":[0.00001113215,0.0002660153,0.02637395,0.000007660557,0.00001635482,0.0006470648,0.00006006166,0.0009453263,0.9660521,0.00005564186,0.005558185,0.000006507956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934569,0.001204541,0.002171864,0.00008814441,0.00002185759,0.00002382125,0.0007298343,0.0001221456,0.002180743],"genre_scores_gemma":[0.9952822,0.0005671041,0.001232927,0.0000479545,0.000006288319,0.00003403293,0.0007389988,0.00002408132,0.002066328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001076608,"threshold_uncertainty_score":0.003601611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01355707053130484,"score_gpt":0.2249370050205988,"score_spread":0.2113799344892939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}