{"id":"W3006518378","doi":"10.3390/epigenomes4010002","title":"Targeting the RNA-Binding Protein QKI in Myeloid Cells Ameliorates Macrophage-Induced Renal Interstitial Fibrosis","year":2020,"lang":"en","type":"article","venue":"Epigenomes","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Leids Universitair Medisch Centrum; Universiteit Leiden; Netherland-America Foundation","keywords":"Biology; Fibrosis; Glomerulosclerosis; Alternative splicing; RNA splicing; Myeloid; Kidney; Cancer research; Messenger RNA; Cell biology; RNA; Gene; Medicine; Pathology; Endocrinology; Proteinuria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002706858,0.0001552033,0.0001502717,0.00004375355,0.0001590765,0.00008188256,0.0003357888,0.00008907056,0.00006619265],"category_scores_gemma":[0.0001600696,0.0001188457,0.00007791365,0.000194999,0.00005739,0.000007427621,0.0002197976,0.0002366161,0.00005666514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002532595,"about_ca_system_score_gemma":0.00007348257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001105908,"about_ca_topic_score_gemma":0.00002632477,"domain_scores_codex":[0.998727,0.0001205136,0.0002322131,0.0003415009,0.0001578534,0.0004209502],"domain_scores_gemma":[0.9995747,0.00001934809,0.00006911896,0.0001718536,0.00003743556,0.0001275011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001093439,0.00001174238,0.0003644527,0.00002109573,0.00002153785,0.00002081695,0.0002580907,0.0001437701,0.9969083,0.000004975062,0.0005175481,0.001618332],"study_design_scores_gemma":[0.0002932578,0.0002791288,0.0001724555,0.00002471581,0.000003062999,8.765023e-7,0.0004811935,0.0003226419,0.9950379,0.000007678807,0.003224036,0.0001530286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972832,0.0005977016,0.0002874502,0.001180077,0.00006875477,0.0003457726,0.00001379544,0.00001360153,0.0002096286],"genre_scores_gemma":[0.9979359,0.00006663716,0.0004759322,0.0001943135,0.0004963797,0.00003887653,0.00003472363,0.00002514965,0.0007321228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002706488,"threshold_uncertainty_score":0.4846386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607102743569273,"score_gpt":0.2539416765701163,"score_spread":0.2378706491344236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}