{"id":"W3006572231","doi":"10.1097/ccm.0000000000004091","title":"Systemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis*","year":2020,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"National Institute of General Medical Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute","keywords":"Medicine; Sepsis; Vascular endothelial growth factor; Angiopoietin; Von Willebrand factor; Endothelial activation; Thrombomodulin; Respiratory distress; Immunology; Internal medicine; Angiopoietin receptor; Endothelium; Angiogenesis; Surgery; Platelet; Thrombin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005965969,0.0001800218,0.000252551,0.00003140535,0.00005094019,0.00000994274,0.0001322362,0.0001456471,0.0000340625],"category_scores_gemma":[0.0001066647,0.0001269093,0.00004081264,0.0001657018,0.000226201,0.000007461018,0.00003294152,0.0001310692,0.000002430359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004214459,"about_ca_system_score_gemma":0.00007068923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003494228,"about_ca_topic_score_gemma":0.000008049677,"domain_scores_codex":[0.9988567,0.00006596951,0.0001914202,0.0003952925,0.0002552238,0.0002354084],"domain_scores_gemma":[0.9994335,0.00002471758,0.00004439762,0.0001811726,0.0001590809,0.0001572027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001109038,0.0001069435,0.7013915,0.0002203468,0.0004889005,0.000390511,0.001027948,0.00001698615,0.2916786,0.0001244059,0.001437354,0.002007466],"study_design_scores_gemma":[0.008214095,0.01279699,0.8579361,0.002074805,0.0007688203,0.000465936,0.002762827,0.00003984623,0.1122089,0.00002071808,0.001497263,0.001213705],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957213,0.001823971,0.0005681655,0.001186145,0.00003284606,0.0002263715,0.0002212542,0.00001905818,0.0002008337],"genre_scores_gemma":[0.9973009,0.00002599707,0.00002037578,0.002020366,0.0002966684,0.00004291455,0.0002356363,0.00003270428,0.00002439957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1794697,"threshold_uncertainty_score":0.5175213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01447766528237225,"score_gpt":0.2701575257308743,"score_spread":0.255679860448502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}