{"id":"W3006584233","doi":"10.1038/s41467-020-14525-4","title":"FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk Fonden; Novo Nordisk; KU Leuven; University of Toronto; Chalmers Tekniska Högskola; VINNOVA","keywords":"Yeast; Toxicity; Metabolism; Redox; Amyloid (mycology); Chemistry; Biochemistry; Cell biology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001246273,0.0003686089,0.0002215361,0.0001845319,0.000123442,0.0002562465,0.0002229331,0.0002165529,0.0007041892],"category_scores_gemma":[0.00008843555,0.00007349443,0.0001555254,0.0001671061,0.0001636026,0.0001080862,0.0001678079,0.0002278327,0.0001691727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002889186,"about_ca_system_score_gemma":0.0001465204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001364245,"about_ca_topic_score_gemma":0.001271073,"domain_scores_codex":[0.9999225,0.00001699543,0.000009209242,0.00002034538,0.00001873363,0.0000122871],"domain_scores_gemma":[0.9999278,0.00001596295,0.00002074774,0.00000864939,0.00001208129,0.00001483119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002009889,0.00002925246,0.0001114606,0.00002394697,0.000003271741,0.0000164825,0.000006024428,0.00006663682,0.9987665,0.00002712318,0.00002591493,0.000722466],"study_design_scores_gemma":[0.00001441769,0.0002334517,0.001703576,0.0000042234,0.00000738764,0.00004419449,0.00001732474,0.0005619623,0.9964932,0.0000296376,0.0008874973,0.000003192179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992928,0.001722003,0.0031039,0.0001399231,0.00004359154,0.00002239919,0.0008822969,0.0001820082,0.0009758754],"genre_scores_gemma":[0.9937328,0.0006707404,0.003638479,0.00005576397,0.000006345254,0.00001780533,0.0007759794,0.0000282597,0.001073722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001364245,"threshold_uncertainty_score":0.002712607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03071373192408664,"score_gpt":0.3294690945213538,"score_spread":0.2987553625972671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}