{"id":"W3006624376","doi":"10.1002/pst.2005","title":"START: single‐to‐double arm transition design for phase II clinical trials","year":2020,"lang":"en","type":"article","venue":"Pharmaceutical Statistics","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Randomization; Frequentist inference; Computer science; Restricted randomization; Null hypothesis; Clinical study design; Clinical trial; Randomized controlled trial; Statistics; Research design; Gold standard (test); Medical physics; Medicine; Mathematics; Surgery; Bayesian probability; Internal medicine; Bayesian inference","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.02216669,0.0005353402,0.002443877,0.00007371628,0.0003072273,0.0001286629,0.0005190884,0.0003650037,0.00196165],"category_scores_gemma":[0.319788,0.0004796264,0.0005242293,0.0004232185,0.000337453,0.0001008826,0.0001552027,0.0008156238,0.000185635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009776677,"about_ca_system_score_gemma":0.0001783876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001493836,"about_ca_topic_score_gemma":5.685975e-7,"domain_scores_codex":[0.9876317,0.004905534,0.004552674,0.001089256,0.0008534717,0.0009673483],"domain_scores_gemma":[0.8068024,0.1898465,0.00058544,0.0003967541,0.0004611614,0.001907825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.03096101,0.009319725,0.000004128763,0.0008970521,0.0007612547,0.00009895299,0.001015142,0.0001553969,0.005775302,0.3656887,0.2058811,0.3794422],"study_design_scores_gemma":[0.03184917,0.01217728,0.000001764219,0.00007601994,0.001999335,0.000004351514,0.00005476513,0.08089796,0.01939208,0.7969835,0.05574078,0.0008229328],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.0006861018,0.00003976919,0.9785313,0.008933083,0.001326423,0.005234835,0.004671003,0.0003164529,0.0002610309],"genre_scores_gemma":[0.01848029,0.00005091447,0.9701976,0.008428275,0.002238593,0.0003548023,0.0000462862,0.000138577,0.00006465007],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.4312949,"threshold_uncertainty_score":0.9997655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9480752190546133,"score_gpt":0.7157514049968547,"score_spread":0.2323238140577586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}