{"id":"W3006680797","doi":"10.1021/acschembio.0c00112","title":"Covalent Immune Recruiters: Tools to Gain Chemical Control Over Immune Recognition","year":2020,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Prostate Cancer Canada; Institute of Cancer Research; McMaster University; Cancer Research Society","keywords":"Immune system; Covalent bond; Biology; Computational biology; Chemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006878528,0.0005414248,0.0002007889,0.0003194898,0.0002275108,0.0004893197,0.0005921235,0.0006810118,0.001865993],"category_scores_gemma":[0.0006183733,0.0002792439,0.0002667514,0.0001788628,0.0006410283,0.0008230614,0.0005327919,0.001090261,0.0006074118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004073092,"about_ca_system_score_gemma":0.0002425566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002489822,"about_ca_topic_score_gemma":0.0004449776,"domain_scores_codex":[0.9996362,0.00007348835,0.00002056846,0.00008552966,0.0001184237,0.00006570957],"domain_scores_gemma":[0.9996719,0.00007675377,0.0001408155,0.00004587309,0.00003023592,0.0000343436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008673409,0.00008947964,0.0002441221,0.00041259,0.00002094386,0.0001211414,0.00008150244,0.0006924167,0.956151,0.01453687,0.001070951,0.02649224],"study_design_scores_gemma":[0.00003132553,0.0005446165,0.0002933986,0.00002261274,0.00001553143,0.0002510526,0.00002522438,0.002072833,0.963721,0.0008530597,0.03214294,0.00002641325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5302405,0.02759916,0.3972985,0.002645271,0.0008866896,0.0005274174,0.0006277649,0.002351281,0.03782335],"genre_scores_gemma":[0.8935556,0.008719544,0.08603473,0.001277859,0.0002347987,0.0003061269,0.0002471323,0.0001549631,0.009469301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001865993,"threshold_uncertainty_score":0.006242335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0764224510931147,"score_gpt":0.3366260907967386,"score_spread":0.2602036397036239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}