{"id":"W3006689747","doi":"10.1101/2020.02.21.960153","title":"Silencing branched-chain ketoacid dehydrogenase or treatment with branched-chain ketoacids ex vivo inhibits muscle insulin signaling","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Saint John Regional Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Dalhousie University; Diabetes Canada; Fondation de la recherche en santé du Nouveau-Brunswick","keywords":"Internal medicine; Endocrinology; Skeletal muscle; Biology; Insulin; Insulin receptor; Protein kinase B; mTORC1; Catabolism; Carbohydrate metabolism; Branched-chain amino acid; Biochemistry; Metabolism; Signal transduction; Insulin resistance; Amino acid; Leucine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002093117,0.0004242732,0.000334877,0.0001973323,0.0001781056,0.0003649119,0.0003145594,0.0003342413,0.00221225],"category_scores_gemma":[0.00008301872,0.0001865773,0.0003379197,0.0001680931,0.0003781114,0.0002376622,0.0002369357,0.0009995322,0.0005910131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003028879,"about_ca_system_score_gemma":0.0002879823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007680177,"about_ca_topic_score_gemma":0.001366621,"domain_scores_codex":[0.9997395,0.00003241916,0.00003903351,0.00008015392,0.00005469568,0.0000541534],"domain_scores_gemma":[0.9998879,0.0000180926,0.00002867224,0.00001724506,0.000009440651,0.00003860842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001166922,0.00002551389,0.00005259466,0.00004146561,0.000004743668,0.00001136191,0.000008864656,0.00002253475,0.9990122,0.00006438878,0.00007219017,0.0005673537],"study_design_scores_gemma":[0.00003169514,0.0002938174,0.002122136,0.000007252838,0.00001371007,0.00005031012,0.00002485686,0.0005399602,0.9945658,0.00004135431,0.00230495,0.000004017759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790592,0.004351618,0.008284708,0.0006289089,0.0002747882,0.00009620957,0.002804414,0.00048893,0.00401127],"genre_scores_gemma":[0.9737691,0.002956887,0.007808989,0.0003154235,0.00004957443,0.0002661442,0.002657747,0.0001253268,0.01205083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00221225,"threshold_uncertainty_score":0.007400751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0243900572719878,"score_gpt":0.2389048478492727,"score_spread":0.2145147905772849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}