{"id":"W3006752870","doi":"10.1200/jco.2020.38.6_suppl.tps385","title":"DASL-HiCAP (ANZUP1801): The impact of darolutamide on standard therapy for localized very high-risk cancer of the prostate—A randomized phase III double-blind, placebo-controlled trial of adding darolutamide to androgen deprivation therapy and definitive or salvage radiation in very high-risk, clinically localized prostate cancer.","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Medicine; Tolerability; Clinical endpoint; Prostate cancer; Placebo; Androgen deprivation therapy; Internal medicine; Hazard ratio; Oncology; Docetaxel; Hormonal therapy; Antiandrogen; Randomized controlled trial; Urology; Cancer; Adverse effect; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001874351,0.001947452,0.002683089,0.0007367223,0.0004018327,0.00115608,0.001524756,0.001796035,0.008693306],"category_scores_gemma":[0.001526877,0.000813422,0.001578874,0.0005634578,0.001467631,0.0008884464,0.000503879,0.003380051,0.001291172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006268083,"about_ca_system_score_gemma":0.001543721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001003845,"about_ca_topic_score_gemma":0.001890459,"domain_scores_codex":[0.9993708,0.0003877857,0.00002822101,0.00008471686,0.00004961692,0.00007896133],"domain_scores_gemma":[0.9991553,0.0002068701,0.0001602679,0.00005617788,0.00004913464,0.000372201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9728281,0.007194182,0.0002279202,0.001010977,0.0006389451,0.00002845654,0.00003290417,0.000290767,0.0031166,0.0001576017,0.0008919555,0.01358157],"study_design_scores_gemma":[0.9371101,0.06109885,0.0005256593,0.00002520711,0.0001872293,0.0000199834,0.00001159889,0.0001661358,0.0003332502,0.0000575902,0.0004538085,0.00001047041],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727733,0.009919673,0.001010301,0.0007799875,0.0008758164,0.008531401,0.002042819,0.0004240735,0.003642658],"genre_scores_gemma":[0.9744744,0.005366521,0.002207392,0.001126951,0.0005351853,0.009092698,0.001799851,0.00004388029,0.005353029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008693306,"threshold_uncertainty_score":0.029082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1005882058734528,"score_gpt":0.4669067357666523,"score_spread":0.3663185298931996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}