{"id":"W3006825747","doi":"10.1128/msphere.00913-19","title":"Metabolic Reprogramming in the Opportunistic Yeast Candida albicans in Response to Hypoxia","year":2020,"lang":"en","type":"article","venue":"mSphere","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Government of Canada; Fondation CHU de Québec; Centre Hospitalier Universitaire de Québec; Natural Sciences and Engineering Research Council of Canada","keywords":"Lipidome; Metabolome; Candida albicans; Biology; Metabolomics; Ergosterol; Biochemistry; Metabolic pathway; Pentose phosphate pathway; Yeast; Cell biology; Microbiology; Lipidomics; Metabolism; Glycolysis; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007186817,0.0001100333,0.000270922,0.00002919536,0.00003337181,0.00002042611,0.0001456947,0.00005259566,0.0002997474],"category_scores_gemma":[0.00123651,0.00007831591,0.00005932317,0.0005857074,0.00004688384,0.00003265518,0.00003252022,0.0002498674,0.00006675694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004629562,"about_ca_system_score_gemma":0.0001972548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005098038,"about_ca_topic_score_gemma":0.003615132,"domain_scores_codex":[0.9987303,0.000188687,0.0002590666,0.0003131185,0.0002407574,0.0002680519],"domain_scores_gemma":[0.9992831,0.0001102181,0.00002971992,0.0003704473,0.00002734089,0.0001791463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01078299,0.0004330684,0.826035,0.000194192,0.00004200646,0.002891781,0.01712431,0.00002353768,0.04701949,0.0007335195,0.005315772,0.08940434],"study_design_scores_gemma":[0.0007931447,0.0002261675,0.879293,0.00009172121,0.0000276893,0.00001026631,0.006509925,0.00009712482,0.0001071138,0.00003471971,0.1126911,0.0001180458],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983709,0.0004427202,0.00008426913,0.01199303,0.00002656346,0.0004702388,0.000009899301,0.00002659965,0.003237667],"genre_scores_gemma":[0.9944022,0.00002111811,0.0003528503,0.004347056,0.00006594984,0.0000350195,0.000006534497,0.00001326766,0.0007559741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1073753,"threshold_uncertainty_score":0.3282023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04365688164241893,"score_gpt":0.3009801725422692,"score_spread":0.2573232908998502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}