{"id":"W3006828128","doi":"10.1016/j.gde.2020.02.003","title":"DNA methylation of the TERT promoter and its impact on human cancer","year":2020,"lang":"en","type":"review","venue":"Current Opinion in Genetics & Development","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Telomerase; Biology; Telomere; Telomerase reverse transcriptase; DNA methylation; Epigenetics; Cancer; Methylation; Promoter; Cancer research; Genetics; Molecular biology; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000184135,0.0004142458,0.001036048,0.0002129573,0.00006371294,0.00001574788,0.0002036284,0.0001623349,0.0000442641],"category_scores_gemma":[0.00003599816,0.0002528973,0.0001799488,0.0003845014,0.00004459899,0.00001793053,0.0001488387,0.0004202524,0.000009250638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003261037,"about_ca_system_score_gemma":0.0009667897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003692478,"about_ca_topic_score_gemma":0.000002175582,"domain_scores_codex":[0.9978721,0.0001269175,0.0008505034,0.0004557478,0.0004450928,0.0002496156],"domain_scores_gemma":[0.9990738,0.00004385057,0.0003835376,0.0002771947,0.00008182609,0.0001398148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001052555,0.0001100848,0.001189842,0.01520813,0.00009154387,7.943792e-7,0.0006780609,0.000001275723,0.00003449902,0.00001550371,0.0002549227,0.9824048],"study_design_scores_gemma":[0.0004194283,0.0001110338,0.03413274,0.03665616,0.0001335619,0.000009589725,0.00000636398,0.00001646029,0.0004868078,0.000009282429,0.9277063,0.0003122643],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006388481,0.9902412,0.000005971811,0.00008428125,0.001603089,0.001605294,0.00003293365,0.00001371137,0.00002506937],"genre_scores_gemma":[0.003894363,0.9953965,0.0001037721,0.00001337177,0.0002494452,0.000147447,0.0001263714,0.00004014115,0.0000285822],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9820926,"threshold_uncertainty_score":0.9999923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.167215409732332,"score_gpt":0.4593638172505612,"score_spread":0.2921484075182292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}