{"id":"W3006876275","doi":"10.1128/iai.00104-20","title":"<i>De Novo</i> Purine Biosynthesis Is Required for Intracellular Growth of Staphylococcus aureus and for the Hypervirulence Phenotype of a <i>purR</i> Mutant","year":2020,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Virulence; Derepression; Biology; Phenotype; Staphylococcus aureus; Mutant; Microbiology; Virulence factor; Repressor; Human pathogen; Purine; Pathogen; Gene; Genetics; Bacteria; Transcription factor; Psychological repression; Gene expression; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001271189,0.000335428,0.0002497897,0.0001911954,0.0001341033,0.0004218669,0.0002616898,0.0003586788,0.001041955],"category_scores_gemma":[0.0003136233,0.0001373525,0.0002570346,0.0001512964,0.0002499881,0.0001539374,0.0002957295,0.0004432354,0.0007205794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002433514,"about_ca_system_score_gemma":0.0002238744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009758333,"about_ca_topic_score_gemma":0.0008601213,"domain_scores_codex":[0.9997323,0.00005658013,0.00003212985,0.00004200394,0.00009974626,0.00003718395],"domain_scores_gemma":[0.9996245,0.00006809203,0.0001446717,0.00004530841,0.00002997795,0.0000873894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007519383,0.00002332395,0.0003013346,0.00001855829,0.000003941585,0.0001768416,0.00001254009,0.00006404096,0.9983535,0.00009988428,0.00006808659,0.0008028515],"study_design_scores_gemma":[0.0000123127,0.0002259797,0.01048976,0.00001359681,0.00001294766,0.001304564,0.00008040966,0.00164337,0.983559,0.0001311566,0.002510419,0.00001656229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940057,0.0008501912,0.001949258,0.0002345206,0.00003822348,0.00001537875,0.0006386378,0.0001576565,0.002110377],"genre_scores_gemma":[0.9961482,0.0002268428,0.001663809,0.00006091637,0.0000107013,0.00001236677,0.000704124,0.00005593088,0.001117259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001041955,"threshold_uncertainty_score":0.00348568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02979969762573164,"score_gpt":0.2691077450920014,"score_spread":0.2393080474662697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}