{"id":"W3006893670","doi":"10.1101/2020.02.26.965533","title":"Immunotherapy efficacy in colorectal cancer is dependent on activation of a microbial-metabolite-immune circuit","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; International Microbiome Centre, University of Calgary; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Cumming School of Medicine, University of Calgary; Alberta Innovates; Canterbury Medical Research Foundation; National Science Foundation","keywords":"Immunotherapy; Colorectal cancer; Immune checkpoint; Blockade; Immune system; Cancer; Cancer research; Cancer immunotherapy; Inosine; Tumor microenvironment; Biology; Medicine; Immunology; Adenosine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019866,0.0001898218,0.000218866,0.0001590216,0.000107295,0.0003305411,0.00008743027,0.0002232986,0.002171973],"category_scores_gemma":[0.0001596353,0.00007510046,0.0001851269,0.00008396737,0.0001477759,0.0001261543,0.0002476448,0.0004609448,0.0004570553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002128192,"about_ca_system_score_gemma":0.000209265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009390381,"about_ca_topic_score_gemma":0.0001375123,"domain_scores_codex":[0.999896,0.00002940067,0.000005802501,0.00001839913,0.00002731067,0.00002304197],"domain_scores_gemma":[0.9998879,0.00001991352,0.00003972116,0.00000984808,0.00001410912,0.0000285827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000292681,0.0000533128,0.001419394,0.0001038222,0.0000135524,0.00005962483,0.00001168715,0.0001499297,0.9869694,0.0003581873,0.0002162955,0.01035207],"study_design_scores_gemma":[0.00007330912,0.001655749,0.02892854,0.00003373022,0.0000701482,0.0008673583,0.0000502809,0.002104599,0.95282,0.0007051684,0.01268202,0.000009155836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773402,0.009954892,0.005277622,0.0009299036,0.0001343787,0.00006121709,0.0003080243,0.0001987467,0.00579504],"genre_scores_gemma":[0.9941359,0.00137354,0.002573203,0.0001210782,0.00003138592,0.00002956983,0.0001283735,0.00001713866,0.001589766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002171973,"threshold_uncertainty_score":0.007265925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511805442941572,"score_gpt":0.2491063279830848,"score_spread":0.2339882735536691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}