{"id":"W3006898855","doi":"10.1016/j.cell.2020.01.033","title":"TACAN Is an Ion Channel Involved in Sensing Mechanical Pain","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Shriners Hospitals for Children - Canada; Montreal Children's Hospital; Université de Montréal; McMaster University Medical Centre; McGill University","funders":"National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Louise and Alan Edwards Foundation; Agence Nationale de la Recherche","keywords":"Nociceptor; Mechanotransduction; Ion channel; Acid-sensing ion channel; Neuroscience; Nociception; PIEZO1; Biology; Cell biology; Receptor; Biochemistry; Mechanosensitive channels","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001567382,0.00007814766,0.0001739972,0.00003579077,0.00002101326,0.000003688696,0.00002817953,0.0001031449,0.0001876035],"category_scores_gemma":[0.00006248378,0.00007173607,0.00003894587,0.0001333705,0.00001567579,0.00002595398,0.00001918357,0.0001911987,0.000105692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002126412,"about_ca_system_score_gemma":0.00003274276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000247281,"about_ca_topic_score_gemma":0.00002450676,"domain_scores_codex":[0.9993278,0.0001160645,0.0001294158,0.0002135863,0.00007046483,0.0001426242],"domain_scores_gemma":[0.999633,0.0000318251,0.00002730866,0.0001185139,0.00002488942,0.000164523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003152761,0.0001034029,0.0002768332,0.0001049889,0.000005228162,0.0001087372,0.001997076,0.000009625278,0.9880892,0.00002196313,0.006647711,0.002319933],"study_design_scores_gemma":[0.007509771,0.005293247,0.004165659,0.0001823954,0.00007444778,0.00002687556,0.006491592,0.3205191,0.6047325,0.001118482,0.0492529,0.0006329626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899946,0.00006072256,0.002650704,0.005542239,0.0002334002,0.000164713,0.000001965844,0.00007772882,0.001273926],"genre_scores_gemma":[0.9725575,0.00002268269,0.0004514486,0.02635243,0.000386365,0.000001084029,0.00003502571,0.00001352001,0.0001799289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3833567,"threshold_uncertainty_score":0.2925312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04809643322491874,"score_gpt":0.2561701797468437,"score_spread":0.208073746521925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}