{"id":"W3006927029","doi":"10.1007/s00262-020-02514-x","title":"CD1d expression and invariant natural killer T-cell numbers are reduced in patients with upper gastrointestinal cancers and are further impaired by commonly used chemotherapies","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"Ministerio de Ciencia Tecnología y Telecomunicaciones; Consejo Nacional de Ciencia y Tecnología; Health Research Board","keywords":"Granzyme B; Cancer research; Cisplatin; Cytotoxic T cell; Granzyme; CD1D; Medicine; Immunology; Perforin; Biology; Natural killer T cell; Internal medicine; Chemotherapy; T cell; Immune system; CD8; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001118922,0.0002795719,0.00045968,0.0005564261,0.0003045227,0.0004724388,0.000182953,0.0003825084,0.001799776],"category_scores_gemma":[0.0006855204,0.0001561127,0.0002315453,0.0005753483,0.0002482713,0.0002627128,0.0002221264,0.0004215257,0.0002731007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002339243,"about_ca_system_score_gemma":0.0001239221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008003173,"about_ca_topic_score_gemma":0.0007101931,"domain_scores_codex":[0.9998716,0.00002352985,0.00001289954,0.00003416802,0.00002457756,0.00003327044],"domain_scores_gemma":[0.9996939,0.00006350163,0.0001496472,0.00001606341,0.00002849094,0.00004845834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004143271,0.0002146998,0.9219079,0.0001536341,0.0001624311,0.001574926,0.0001780961,0.0001636344,0.03539798,0.0001189936,0.001225489,0.03475889],"study_design_scores_gemma":[0.00002375603,0.0002462576,0.9939334,0.00001046447,0.00008946801,0.001948906,0.0001113137,0.0002086598,0.002161468,0.0001013177,0.001158591,0.00000654503],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972392,0.001416116,0.0001667462,0.00008896091,0.00001403372,0.000005091842,0.0002465207,0.00002146012,0.0008018476],"genre_scores_gemma":[0.998821,0.0003071009,0.00009206132,0.00004599058,0.00001530246,0.000006182564,0.0002435701,0.000004583901,0.0004641731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001799776,"threshold_uncertainty_score":0.006020784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007580762280230378,"score_gpt":0.2088324222365771,"score_spread":0.2012516599563468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}