{"id":"W3006939649","doi":"10.1111/cts.12771","title":"Pharmacogenomics in Asian Subpopulations and Impacts on Commonly Prescribed Medications","year":2020,"lang":"en","type":"review","venue":"Clinical and Translational Science","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Pharmacogenetics; Medicine; Pharmacogenomics; Carbamazepine; Context (archaeology); CYP2C19; Population; Pharmacology; Drug; Internal medicine; Genotype; Genetics; Biology; Psychiatry; Epilepsy; Gene; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006358716,0.0002031249,0.0007688336,0.0002453048,0.0001955181,0.00003592768,0.0001422627,0.0001633563,0.00001097389],"category_scores_gemma":[0.0003586527,0.0001609904,0.000157075,0.0007995972,0.0008996729,0.0001611171,0.00003419685,0.0007239229,0.00002548547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003987733,"about_ca_system_score_gemma":0.001313377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001668533,"about_ca_topic_score_gemma":0.0000404011,"domain_scores_codex":[0.9980012,0.00008543323,0.0007743486,0.0005545428,0.0003679882,0.000216469],"domain_scores_gemma":[0.9983745,0.0006438383,0.0001548212,0.0001796754,0.00005266648,0.0005945149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005019152,0.0001578307,0.001684233,0.0003417127,0.00004049707,0.00001291108,0.00006764018,9.456625e-7,0.000002560341,0.003801382,0.000009307145,0.993876],"study_design_scores_gemma":[0.0008976085,0.00004426394,0.1299411,0.002184036,0.0006351959,0.0001165455,0.00001576474,0.0004530189,3.142397e-7,0.0005767564,0.8649192,0.000216174],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001172254,0.964813,0.00009738828,0.01381823,0.0005010092,0.002192763,0.0003273637,0.0000850371,0.01699298],"genre_scores_gemma":[0.05432528,0.9444877,0.0005381554,0.0002548781,0.0002007673,0.00002752079,0.0001192707,0.00001650716,0.0000299212],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9936598,"threshold_uncertainty_score":0.6564997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1939635517204557,"score_gpt":0.4925846188705731,"score_spread":0.2986210671501174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}