{"id":"W3006977546","doi":"10.1186/s12891-020-3056-4","title":"Human adipose-derived Mesenchymal stem cells, low-intensity pulsed ultrasound, or their combination for the treatment of knee osteoarthritis: study protocol for a first-in-man randomized controlled trial","year":2020,"lang":"en","type":"article","venue":"BMC Musculoskeletal Disorders","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Tongji University; National Natural Science Foundation of China","keywords":"Medicine; Osteoarthritis; WOMAC; Rheumatology; Randomized controlled trial; Clinical trial; Placebo; Adipose tissue; Mesenchymal stem cell; Extracorporeal shockwave therapy; Low-intensity pulsed ultrasound; Sports medicine; Physical therapy; Surgery; Ultrasound; Internal medicine; Pathology; Therapeutic ultrasound; Radiology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003549711,0.0004038281,0.001322086,0.00007290475,0.0002679361,0.00005722795,0.0002257562,0.0001049793,0.0000442315],"category_scores_gemma":[0.0001365412,0.0002450564,0.001052622,0.0001866479,0.0001263524,0.00009056454,0.00001134451,0.00009068605,0.000003138866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006777263,"about_ca_system_score_gemma":0.0000516879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004511735,"about_ca_topic_score_gemma":0.002260444,"domain_scores_codex":[0.9980677,0.0001687981,0.000856451,0.0003709548,0.0001933523,0.0003427957],"domain_scores_gemma":[0.996892,0.00239908,0.0001917423,0.0003226278,0.0001078092,0.00008678446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9647118,0.005596807,0.0003694494,0.001070263,0.001513047,5.420128e-7,0.007454165,0.008021544,0.006186327,0.0002479749,0.00008514427,0.004742867],"study_design_scores_gemma":[0.9724069,0.005702455,0.0003167386,0.00003315242,0.0003730993,3.018184e-7,0.003075778,0.01658563,0.0004399112,0.0001575026,0.0005889813,0.0003195259],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5239283,0.00004579512,0.004467036,0.0001059529,0.0001107299,0.4710809,0.00004552682,0.0001526191,0.00006310504],"genre_scores_gemma":[0.5595995,0.000007556127,0.00006151585,0.00001075601,0.00005551966,0.4401791,0.00001821122,0.0000422063,0.00002565267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03567114,"threshold_uncertainty_score":0.999311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01959427762368005,"score_gpt":0.2676345335964825,"score_spread":0.2480402559728025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}