{"id":"W3007071335","doi":"10.1182/blood.v130.suppl_1.2553.2553","title":"Pharmacokinetics and Pharmacodynamics of Tocilizumab for the Management of Cytokine Release Syndrome (CRS) in Pediatric and Young Adult Patients with Relapsed/Refractory (R/R) B-Cell Acute Lymphoblastic Leukemia (B-ALL) Treated with CAR T-Cell Therapy, CTL019","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Pharmacodynamics; Medicine; Cytokine release syndrome; Pharmacokinetics; Tocilizumab; Internal medicine; Pharmacology; Oncology; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005401176,0.0002022093,0.0004150219,0.0001686251,0.0001111745,0.0005168552,0.0001801705,0.0003014702,0.0007247543],"category_scores_gemma":[0.0009514953,0.0001665093,0.0003029757,0.0001761877,0.0001973214,0.0002759061,0.0001246321,0.0007468673,0.0002246272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004986789,"about_ca_system_score_gemma":0.0003729855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005056204,"about_ca_topic_score_gemma":0.001095022,"domain_scores_codex":[0.9997446,0.00009169691,0.00001780133,0.00004901624,0.00005945378,0.00003751738],"domain_scores_gemma":[0.9996031,0.0000975414,0.0001449076,0.00002761763,0.00002796069,0.00009881372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1291007,0.00502919,0.2040033,0.0005336555,0.001251701,0.001177025,0.0008930854,0.01217519,0.4287759,0.000638537,0.004405519,0.2120161],"study_design_scores_gemma":[0.007100293,0.1649302,0.6666545,0.0001012784,0.00136706,0.003775531,0.0004070593,0.02443351,0.1175859,0.0003309427,0.01321469,0.00009907444],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973985,0.001172476,0.0004680071,0.00006847732,0.00000922854,0.00005624916,0.0003291322,0.00003276019,0.0004651704],"genre_scores_gemma":[0.9984169,0.0002798596,0.0004594112,0.00009570012,0.00001323421,0.00005292124,0.0003564374,0.000008962762,0.0003166381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007247543,"threshold_uncertainty_score":0.003618181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009843819103986807,"score_gpt":0.2545859916300531,"score_spread":0.2447421725260663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}