{"id":"W3007126611","doi":"10.1038/s41398-020-0753-6","title":"Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion","year":2020,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Tau Consortium; Stanley Center for Psychiatric Research, Broad Institute; National Institute of Mental Health; U.S. Department of Health and Human Services","keywords":"Lithium (medication); Phosphorylation; Stable isotope labeling by amino acids in cell culture; Amphetamine; Kinase; GSK-3; Chemistry; Protein phosphorylation; Neuroscience; Pharmacology; Protein kinase A; Induced pluripotent stem cell; Cell biology; Biochemistry; Proteomics; Medicine; Biology; Internal medicine; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008829391,0.0003094908,0.0002985499,0.0002525717,0.000121743,0.0002024442,0.0001633415,0.0001691239,0.000917403],"category_scores_gemma":[0.00007661152,0.0001261336,0.0002016526,0.0001470795,0.0001360278,0.00009896523,0.0001044098,0.0004011274,0.0001648275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00020441,"about_ca_system_score_gemma":0.0001736868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005369564,"about_ca_topic_score_gemma":0.002327129,"domain_scores_codex":[0.9999541,0.000005407148,0.000005507782,0.000009651683,0.00001463799,0.00001073123],"domain_scores_gemma":[0.9999613,0.000005644634,0.00001480684,0.000003277867,0.000004120186,0.00001089762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001381357,0.00003914203,0.000155804,0.00002965008,0.000009635009,0.00004567416,0.000006949473,0.00009635418,0.9979239,0.00005044659,0.00005015722,0.001454213],"study_design_scores_gemma":[0.00007744609,0.001295774,0.005165954,0.00000721445,0.00004443378,0.0003484903,0.00001980068,0.001237136,0.989768,0.00002968004,0.001998418,0.000007771914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951389,0.0009962745,0.001203842,0.00009263583,0.00002193104,0.00006392303,0.0005981818,0.0001206279,0.001763665],"genre_scores_gemma":[0.9946176,0.0009900149,0.001988592,0.00008022681,0.000006751141,0.00006903878,0.0008093234,0.0000213632,0.001416957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000917403,"threshold_uncertainty_score":0.003069043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06322017557173897,"score_gpt":0.2911601090455224,"score_spread":0.2279399334737834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}