{"id":"W3007137838","doi":"10.1016/j.celrep.2020.01.072","title":"Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Institute for Translational Neuroscience; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Labex; Universidade Federal do Rio de Janeiro; Agence Nationale de la Recherche; Human Frontier Science Program; John Simon Guggenheim Memorial Foundation","keywords":"Microglia; Hippocampus; Cerebrospinal fluid; Endocrinology; Synaptic plasticity; Internal medicine; Tumor necrosis factor alpha; Medicine; Morris water navigation task; Cognitive decline; Memory impairment; Inflammation; Dementia; Atrophy; Neuroscience; Psychology; Cognition; Receptor; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003648313,0.0001617301,0.0001917195,0.00008950436,0.00008223645,0.00004055766,0.0001375102,0.00004290159,0.00002998156],"category_scores_gemma":[0.00007490334,0.0001208766,0.00003114242,0.0002951718,0.00008001857,0.0001640613,0.00005405816,0.000192231,0.000004342655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001581523,"about_ca_system_score_gemma":0.00009941516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000352332,"about_ca_topic_score_gemma":0.00003256871,"domain_scores_codex":[0.9981767,0.000250823,0.0005168118,0.000486658,0.000385165,0.0001838189],"domain_scores_gemma":[0.9992466,0.00006904029,0.0003130851,0.0002528269,0.00002980342,0.00008862903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005492092,0.0001027059,0.004896588,0.00008517893,8.805077e-7,0.0009244569,0.002784326,0.00006353416,0.9909209,0.00004221034,0.00006753745,0.00005678462],"study_design_scores_gemma":[0.0004273907,0.0002491505,0.02679691,0.00002058,0.000007474777,0.0001317556,0.0001770216,0.0005092738,0.9713867,0.0001054867,0.00006076627,0.0001274698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979312,0.00001753813,0.00004441215,0.0004663824,0.00005525086,0.0006895472,0.000002009251,0.00003070851,0.0007629617],"genre_scores_gemma":[0.99792,0.00002061006,0.00007385965,0.001860338,0.00002435288,0.00003234682,0.000001693154,0.0000149081,0.00005193792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02190032,"threshold_uncertainty_score":0.4929205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02322715284258646,"score_gpt":0.2265203379532062,"score_spread":0.2032931851106198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}