{"id":"W3007141947","doi":"10.1093/jcag/gwz047.030","title":"A31 ALTERED SMALL INTESTINAL EPITHELIAL HOMEOSTASIS AND CELL FATE DECISION UPON LOSS OF TRP53 IN KRT15+ INTESTINAL STEM CELLS","year":2020,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"LGR5; Stem cell; Biology; Cancer stem cell; Stem cell marker; Adult stem cell; Crypt; Cell biology; Multipotent Stem Cell; Intestinal epithelium; Colorectal cancer; Cancer research; Cellular differentiation; Immunology; Cancer; Epithelium; Endocrinology; Progenitor cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001049754,0.0001751068,0.0001957159,0.0002542005,0.00009583939,0.0002497106,0.0001482045,0.0002707666,0.001793268],"category_scores_gemma":[0.00008916617,0.0001049209,0.0002301896,0.000125721,0.0001770709,0.000174858,0.000140966,0.0004168381,0.0004829788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001493644,"about_ca_system_score_gemma":0.00009710096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000361729,"about_ca_topic_score_gemma":0.0002752828,"domain_scores_codex":[0.9998829,0.00001168622,0.00001984686,0.00002675875,0.00003044138,0.00002824684],"domain_scores_gemma":[0.99985,0.00001890275,0.00004842562,0.00001886792,0.00001528551,0.00004854965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001099097,0.00001927522,0.0008275561,0.00002048882,0.000003470098,0.0001090653,0.00001366922,0.00003769165,0.9980216,0.00004576828,0.00001770799,0.0007737129],"study_design_scores_gemma":[0.0000181734,0.0006296716,0.02706203,0.00000865417,0.00002324309,0.00111938,0.00009059158,0.001348817,0.9676904,0.00006730223,0.00193504,0.000006731266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976556,0.0003751973,0.001023246,0.00002994974,0.00001105935,0.0000123828,0.0003540583,0.00004072084,0.0004977208],"genre_scores_gemma":[0.9979095,0.0001438942,0.0004914979,0.00001643766,0.000002108802,0.00001416554,0.0004191212,0.000007282345,0.0009959782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793268,"threshold_uncertainty_score":0.005999088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01330109081922457,"score_gpt":0.2331068456954624,"score_spread":0.2198057548762379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}