{"id":"W3007144859","doi":"10.1016/s2468-1253(19)30421-2","title":"Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in virologically suppressed patients with chronic hepatitis B: a randomised, double-blind, phase 3, multicentre non-inferiority study","year":2020,"lang":"en","type":"article","venue":"The Lancet. Gastroenterology & hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Society of Intestinal Research; Toronto General Hospital","funders":"Gilead Sciences","keywords":"Tenofovir alafenamide; Tenofovir; Medicine; Chronic hepatitis; Double blind; Virology; Pharmacology; Internal medicine; Human immunodeficiency virus (HIV); Viral load; Antiretroviral therapy; Virus; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001892901,0.001481235,0.002511823,0.0003665993,0.0003941643,0.0009745901,0.0007571547,0.00174468,0.004913172],"category_scores_gemma":[0.002034873,0.0006158304,0.002132968,0.0004120417,0.001198051,0.0009618743,0.0003359929,0.002307761,0.0006265786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007963174,"about_ca_system_score_gemma":0.0008603566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001467879,"about_ca_topic_score_gemma":0.002588642,"domain_scores_codex":[0.999043,0.0005332471,0.00006591215,0.000124604,0.00007320015,0.0001599216],"domain_scores_gemma":[0.9987129,0.0005434105,0.0002264823,0.0001153568,0.00007387899,0.0003280026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9825801,0.003217112,0.0004499992,0.0004539544,0.0008968626,0.0000278911,0.00005987518,0.0001434625,0.002149294,0.00005160834,0.0002634156,0.009706362],"study_design_scores_gemma":[0.9537487,0.04325572,0.001888539,0.00002358776,0.0003935155,0.0000212531,0.0000229682,0.0001214725,0.0002232351,0.00008279312,0.0002060106,0.00001228217],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939744,0.003055661,0.0002830535,0.0002911862,0.0003257733,0.0008024768,0.000374725,0.00003770754,0.0008551034],"genre_scores_gemma":[0.9948335,0.00140064,0.0006435285,0.0005570382,0.0002296155,0.0009358754,0.0003584853,0.00001164636,0.001029806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004913172,"threshold_uncertainty_score":0.01643622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02793729444813475,"score_gpt":0.2909359758303985,"score_spread":0.2629986813822638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}