{"id":"W3007144859","doi":"10.1016/s2468-1253(19)30421-2","title":"Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in virologically suppressed patients with chronic hepatitis B: a randomised, double-blind, phase 3, multicentre non-inferiority study","year":2020,"lang":"en","type":"article","venue":"The Lancet. Gastroenterology & hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Society of Intestinal Research; Toronto General Hospital","funders":"Gilead Sciences","keywords":"Tenofovir alafenamide; Tenofovir; Medicine; Chronic hepatitis; Double blind; Virology; Pharmacology; Internal medicine; Human immunodeficiency virus (HIV); Viral load; Antiretroviral therapy; Virus; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005811469,0.0009320996,0.003161752,0.0002559891,0.00035921,0.00006118511,0.0008723984,0.0003336321,0.0001777547],"category_scores_gemma":[0.0002051502,0.0006522671,0.0002373897,0.0004780156,0.000430017,0.000205807,0.0007772074,0.001553551,0.0001839288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004009835,"about_ca_system_score_gemma":0.0002425132,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.008742359,"about_ca_topic_score_gemma":0.1681629,"domain_scores_codex":[0.9931736,0.001061229,0.00147766,0.001691546,0.0005894952,0.002006442],"domain_scores_gemma":[0.9970136,0.0004243239,0.0005272517,0.001140283,0.0002826758,0.0006118523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2117051,0.002260162,0.7785128,0.00005794803,0.0007428364,0.0008974862,0.002912227,0.00008100912,0.00173964,0.000002110547,0.0003262967,0.0007622909],"study_design_scores_gemma":[0.2704817,0.01117829,0.7135149,0.00006702771,0.0004781126,0.00002656269,0.0001170816,0.003343641,0.00005834348,0.00001210746,0.0004018796,0.000320271],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791118,0.000118772,0.002307747,0.01005886,0.0003607079,0.007554605,0.000201206,0.0002238287,0.00006245942],"genre_scores_gemma":[0.9837609,0.0001390719,0.0006040865,0.01314094,0.0005726033,0.001469624,0.0001969879,0.000105241,0.00001055349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1594205,"threshold_uncertainty_score":0.9995928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02793729444813475,"score_gpt":0.2909359758303985,"score_spread":0.2629986813822638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}