{"id":"W3007146897","doi":"10.1371/journal.pone.0229085","title":"Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS)","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Chemical Analysis and Environmental Impact","field":"Environmental Science","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Alberta Innovates; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Western Canada Research Grid; Compute Canada","keywords":"Symporter; Iodide; Sodium-iodide symporter; Chemistry; Perchlorate; Danio; Biochemistry; Biology; Zebrafish; Gene; Transporter; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002258216,0.0001400061,0.0001605031,0.0004500219,0.0002222786,0.0003242695,0.000239369,0.000296933,0.0005398978],"category_scores_gemma":[0.0003067419,0.0001450576,0.0002210283,0.0002525975,0.0003359863,0.0002433765,0.0003739977,0.0002471624,0.0001515203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002738913,"about_ca_system_score_gemma":0.000122238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001369508,"about_ca_topic_score_gemma":0.002185215,"domain_scores_codex":[0.9997776,0.00002207763,0.00002515209,0.00009935688,0.00005019618,0.00002558775],"domain_scores_gemma":[0.9997897,0.00004369048,0.00006437102,0.00002438346,0.00004831107,0.00002969594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007628027,0.0000128419,0.007584967,0.00003373547,0.00002782957,0.00006879364,0.0001683667,0.00004927242,0.9902641,0.00008045247,0.00002783483,0.001605548],"study_design_scores_gemma":[0.0000101049,0.000607071,0.6665769,0.0000193077,0.0001367463,0.002029202,0.0006465073,0.001314084,0.3237171,0.0002788893,0.004612045,0.00005203777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998136,0.0003196247,0.0007530252,0.00001423206,0.00000479405,0.000007161107,0.0002219929,0.00001206975,0.0005312014],"genre_scores_gemma":[0.9976671,0.0001982575,0.0009901272,0.00003647538,0.000001974211,0.00001467111,0.0005086919,0.00001253604,0.0005702306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369508,"threshold_uncertainty_score":0.002723157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03366628123021962,"score_gpt":0.1925504747796877,"score_spread":0.1588841935494681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}