{"id":"W3007162511","doi":"10.1073/pnas.1919893117","title":"Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Research Executive Agency; Canadian Institutes of Health Research; Fondation Leducq; European Commission; Arthritis Research UK; Bayer HealthCare; Cancer Research UK; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Medical Research Council; Versus Arthritis; Ministero dello Sviluppo Economico; Kennedy Trust for Rheumatology Research; National Institute for Health and Care Research; Genome Canada; Pfizer; Eli Lilly and Company","keywords":"Biology; Demethylase; Effector; Cell biology; Transcription factor; Chromatin; Reprogramming; Histone; Cytokine; Epigenetics; T cell; Immune system; Cell; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000452988,0.0001059159,0.000167025,0.00007734388,0.0004549872,0.000009726693,0.0002433656,0.00008847293,0.00003054394],"category_scores_gemma":[0.0001680817,0.00006845027,0.00004993442,0.0002644862,0.0003760411,0.0001413468,0.00007067488,0.0001088956,0.000009824818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002143903,"about_ca_system_score_gemma":0.0000198326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005188312,"about_ca_topic_score_gemma":4.675875e-8,"domain_scores_codex":[0.9992636,0.00001529748,0.0002139156,0.000222218,0.0001520872,0.0001328322],"domain_scores_gemma":[0.9994984,0.0001375143,0.0002691001,0.000005724959,0.00006731684,0.00002196152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003397891,0.00004472921,0.001335842,0.00002576903,0.00005140512,3.216158e-9,0.0004057588,0.000002920602,0.993216,0.0007278629,0.002453789,0.001701955],"study_design_scores_gemma":[0.0003836135,0.00007957836,0.03173291,0.00002242003,0.00004585306,0.000002107263,0.0001327988,0.00000237866,0.9635544,0.0002587962,0.00371114,0.00007405109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956276,0.001657085,4.57258e-7,0.001101227,0.00003419746,0.0001257531,0.00003776589,0.00001519323,0.001400679],"genre_scores_gemma":[0.9990197,0.0000174891,0.0002150535,0.0001839531,0.00002817514,0.00001049951,0.000002012892,0.000003623517,0.0005195239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03039707,"threshold_uncertainty_score":0.3499439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04190085533888743,"score_gpt":0.2861842599851161,"score_spread":0.2442834046462287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}