{"id":"W3007162511","doi":"10.1073/pnas.1919893117","title":"Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Research Executive Agency; Canadian Institutes of Health Research; Fondation Leducq; European Commission; Arthritis Research UK; Bayer HealthCare; Cancer Research UK; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Medical Research Council; Versus Arthritis; Ministero dello Sviluppo Economico; Kennedy Trust for Rheumatology Research; National Institute for Health and Care Research; Genome Canada; Pfizer; Eli Lilly and Company","keywords":"Biology; Demethylase; Effector; Cell biology; Transcription factor; Chromatin; Reprogramming; Histone; Cytokine; Epigenetics; T cell; Immune system; Cell; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009663983,0.0001731656,0.0001306102,0.0001632298,0.0001078062,0.000205447,0.00008244155,0.0001279355,0.001521443],"category_scores_gemma":[0.00007489757,0.0001026201,0.0001247459,0.000102271,0.0001432046,0.00007414649,0.0001227718,0.0002899023,0.0003576146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001945312,"about_ca_system_score_gemma":0.0002251798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006313373,"about_ca_topic_score_gemma":0.00180388,"domain_scores_codex":[0.9999574,0.000006754789,0.000003319442,0.000008717869,0.00001185301,0.00001189041],"domain_scores_gemma":[0.9999728,0.000003869531,0.000008048836,0.000003991453,0.000003624769,0.000007624993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002558281,0.00002274884,0.0008951598,0.00005411427,0.00001054414,0.00004543379,0.0000106542,0.00009983291,0.9911377,0.00006341036,0.0002198958,0.007184715],"study_design_scores_gemma":[0.00007177069,0.0002966234,0.03161117,0.00001037719,0.00003432945,0.0004703171,0.00005257676,0.0006441117,0.9562799,0.0001306838,0.0103909,0.000007163751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740977,0.01412884,0.003225632,0.0005048322,0.00007631166,0.00004944581,0.0008331719,0.0002062343,0.006877931],"genre_scores_gemma":[0.9893008,0.005424501,0.001220522,0.000119717,0.00001379001,0.00002034792,0.0006106581,0.00001744585,0.003272195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001521443,"threshold_uncertainty_score":0.0050897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04190085533888743,"score_gpt":0.2861842599851161,"score_spread":0.2442834046462287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}