{"id":"W3007168498","doi":"10.3324/haematol.2020.248385","title":"FcγRI and FcγRIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopenia","year":2020,"lang":"en","type":"letter","venue":"Haematologica","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Blood Services; Sunnybrook Health Science Centre; Health Sciences Centre; University Health Network; St. Michael's Hospital","funders":"National Center for Advancing Translational Sciences; Department of Medicine, University of Toronto; Health Canada; National Cancer Institute; University of Rochester; University of Toronto; National Center for Research Resources; Medical Center, University of Rochester; Amgen; Lunds Universitet; National Institutes of Health; Toronto General Hospital Research Institute, University Health Network; Universiteit van Amsterdam; Canadian Blood Services; Amsterdam University Medical Centers; Australian Government; Pfizer","keywords":"Autoantibody; Immune thrombocytopenia; Opsonin; Phagocytosis; Platelet; Immunology; Immune system; Antibody; Glycoprotein; Platelet Glycoprotein GPIb-IX Complex; Platelet membrane glycoprotein; Medicine; Biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001222308,0.0006549332,0.0009045329,0.000335629,0.001607136,0.001383831,0.00101723,0.01763216,0.003308969],"category_scores_gemma":[0.004018491,0.0005005596,0.0007520979,0.0001663656,0.00108452,0.001152856,0.0005596392,0.007454664,0.00203248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002481096,"about_ca_system_score_gemma":0.0006452301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002261954,"about_ca_topic_score_gemma":0.002331941,"domain_scores_codex":[0.9992927,0.0002863304,0.00006967044,0.00005708085,0.0001408505,0.0001533186],"domain_scores_gemma":[0.9986847,0.0008594789,0.00007510387,0.00007447856,0.0001691409,0.000137092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002654916,0.0006530547,0.01109813,0.0003603154,0.0001701427,0.2184379,0.0009097029,0.0004841089,0.009754607,0.01470024,0.7069414,0.03383553],"study_design_scores_gemma":[0.002789678,0.001498531,0.02974475,0.0006826133,0.0004307722,0.259415,0.002246444,0.01195554,0.01477093,0.04048491,0.6357977,0.0001832011],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.06885651,0.01157653,0.001264096,0.8398979,0.02563408,0.0000962953,0.0001239164,0.0001276689,0.05242304],"genre_scores_gemma":[0.5107777,0.006873254,0.001331585,0.3494729,0.08318666,0.0001524888,0.000129021,0.00006301435,0.04801342],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01763216,"threshold_uncertainty_score":0.01800174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02357417573987832,"score_gpt":0.2716356772221767,"score_spread":0.2480615014822984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}