{"id":"W3007168498","doi":"10.3324/haematol.2020.248385","title":"FcγRI and FcγRIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopenia","year":2020,"lang":"en","type":"letter","venue":"Haematologica","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Blood Services; Sunnybrook Health Science Centre; Health Sciences Centre; University Health Network; St. Michael's Hospital","funders":"National Center for Advancing Translational Sciences; Department of Medicine, University of Toronto; Health Canada; National Cancer Institute; University of Rochester; University of Toronto; National Center for Research Resources; Medical Center, University of Rochester; Amgen; Lunds Universitet; National Institutes of Health; Toronto General Hospital Research Institute, University Health Network; Universiteit van Amsterdam; Canadian Blood Services; Amsterdam University Medical Centers; Australian Government; Pfizer","keywords":"Autoantibody; Immune thrombocytopenia; Opsonin; Phagocytosis; Platelet; Immunology; Immune system; Antibody; Glycoprotein; Platelet Glycoprotein GPIb-IX Complex; Platelet membrane glycoprotein; Medicine; Biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001830868,0.001002121,0.004591527,0.0004476744,0.000132778,0.00004913259,0.0004066133,0.001261499,0.0006965291],"category_scores_gemma":[0.0002393043,0.0007564895,0.0004075902,0.0005156934,0.0003825798,0.0001005025,0.0002759927,0.001970415,0.000267678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009711432,"about_ca_system_score_gemma":0.0001729329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002292057,"about_ca_topic_score_gemma":0.0000155538,"domain_scores_codex":[0.9956234,0.0002491308,0.00125329,0.001242154,0.0007150959,0.0009169934],"domain_scores_gemma":[0.9978762,0.0003426158,0.0007391399,0.0007792726,0.00008272896,0.0001800828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005866246,0.00265087,0.01280175,0.009728976,0.004600688,0.6139429,0.001521839,0.000005202378,0.03172633,0.0002026853,0.3095323,0.007420304],"study_design_scores_gemma":[0.1466669,0.02105772,0.1573292,0.02345753,0.008139221,0.03288402,0.0006764177,0.0009689774,0.3544808,0.005894536,0.2380002,0.01044443],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.851059,0.005457175,0.000003296224,0.1394471,0.0002275496,0.002226933,0.0002434731,0.0001831712,0.001152235],"genre_scores_gemma":[0.9317477,0.004434557,0.0006700849,0.06142326,0.000173562,0.0001626937,0.00090317,0.0001402961,0.0003446846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5810589,"threshold_uncertainty_score":0.9994886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02357417573987832,"score_gpt":0.2716356772221767,"score_spread":0.2480615014822984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}