{"id":"W3007183689","doi":"10.1016/j.kint.2020.01.029","title":"Connectivity mapping of a chronic kidney disease progression signature identified lysine deacetylases as novel therapeutic targets","year":2020,"lang":"en","type":"article","venue":"Kidney International","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University Health Network; Toronto Rehabilitation Institute; University of Toronto","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Kidney disease; Lysine; Signature (topology); Disease; Medicine; Biology; Computational biology; Cancer research; Bioinformatics; Pathology; Internal medicine; Genetics; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001151619,0.0002418472,0.0002755598,0.0005633979,0.0002644329,0.0003968151,0.0002134558,0.0001951936,0.002321098],"category_scores_gemma":[0.0003775258,0.00009241021,0.0003642053,0.0006156575,0.0001382159,0.0002380798,0.0002603008,0.0003224457,0.0002699626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003322487,"about_ca_system_score_gemma":0.0004698199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003495447,"about_ca_topic_score_gemma":0.0060194,"domain_scores_codex":[0.9999468,0.000005837447,0.00000250126,0.00001888104,0.00001317478,0.00001271057],"domain_scores_gemma":[0.9998907,0.00002651286,0.00003112921,0.000008138946,0.0000220232,0.00002145611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001706935,0.0002160339,0.1005543,0.0007895477,0.0008625093,0.001511068,0.0003770004,0.02005444,0.6324933,0.009288027,0.008521156,0.2236257],"study_design_scores_gemma":[0.0002174231,0.000890761,0.7003022,0.0001531125,0.001084877,0.003987847,0.0005002746,0.1411091,0.1044077,0.02349859,0.02371583,0.0001322467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9389281,0.001416934,0.04791959,0.0006362196,0.00006869042,0.00006479699,0.004790138,0.0004964815,0.005679022],"genre_scores_gemma":[0.9835327,0.0004988725,0.01274182,0.00006304256,0.00002196144,0.00004946582,0.001800889,0.00004869136,0.001242535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003495447,"threshold_uncertainty_score":0.007764816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01876532565654504,"score_gpt":0.3040742068170449,"score_spread":0.2853088811604998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}