{"id":"W3007184647","doi":"10.3390/pathogens9020147","title":"Recognition of Lipoproteins by Toll-like Receptor 2 and DNA by the AIM2 Inflammasome Is Responsible for Production of Interleukin-1β by Virulent Suilysin-Negative Streptococcus suis Serotype 2","year":2020,"lang":"en","type":"article","venue":"Pathogens","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Inflammasome; Streptococcus suis; TLR2; Biology; Microbiology; Virulence; AIM2; Pathogen; Serotype; Immunology; Interleukin; Inflammation; Virology; Cytokine; TLR4; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001802676,0.0002071159,0.0003679107,0.0000656626,0.0001050214,0.00001307316,0.00006084892,0.000107579,0.0002070988],"category_scores_gemma":[0.0003699415,0.000154174,0.000133691,0.0003181762,0.0001673169,0.00009852155,0.00004191515,0.0001285092,0.00001173313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007184311,"about_ca_system_score_gemma":0.00006820634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001390645,"about_ca_topic_score_gemma":0.00002457959,"domain_scores_codex":[0.9986621,0.00009598586,0.0004280926,0.0004135499,0.0001988326,0.0002014034],"domain_scores_gemma":[0.9989427,0.0001394648,0.0002685295,0.0002672386,0.0002541394,0.0001279313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001084066,0.0003766399,0.01463185,0.0001616815,0.0003296096,0.000001107138,0.00130166,5.534976e-7,0.9338287,0.000008714025,0.03148317,0.01679223],"study_design_scores_gemma":[0.001684401,0.002154766,0.001549876,0.0001295787,0.0002927012,0.000006218461,0.0006553972,0.00003635405,0.980082,0.0001197397,0.01314451,0.0001444221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922552,0.0003442988,0.0001226313,0.002328418,0.0001425557,0.002810984,0.00183675,0.00003811765,0.0001210579],"genre_scores_gemma":[0.9968041,0.0001947832,0.0006298564,0.0002359384,0.0001170709,0.000663631,0.0004591162,0.00003785438,0.000857668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04625332,"threshold_uncertainty_score":0.6287034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02799481491319631,"score_gpt":0.2691819224288243,"score_spread":0.241187107515628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}