{"id":"W3007279081","doi":"10.1007/s11010-020-03703-z","title":"Inside(sight) of tiny communicator: exosome biogenesis, secretion, and uptake","year":2020,"lang":"en","type":"review","venue":"Molecular and Cellular Biochemistry","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":214,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Microvesicles; Biogenesis; Exosome; Secretion; Cell biology; Endosome; Extracellular vesicles; Extracellular vesicle; Biology; Vesicle; Extracellular; ESCRT; Intracellular; Cell type; Microvesicle; Cell; microRNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005671919,0.000980927,0.001448698,0.001382894,0.0003335296,0.001781595,0.0009814149,0.001973863,0.003779919],"category_scores_gemma":[0.0007622619,0.0003270189,0.0004158609,0.00137245,0.000828396,0.002282838,0.001089953,0.002339513,0.003569352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007562829,"about_ca_system_score_gemma":0.001004317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006924024,"about_ca_topic_score_gemma":0.001185039,"domain_scores_codex":[0.999798,0.00002847353,0.00002513715,0.000037881,0.00008416588,0.00002637463],"domain_scores_gemma":[0.9997821,0.00009032191,0.00003572394,0.000009742513,0.00005233517,0.00002968609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001135753,0.00003797716,0.0001184937,0.01094326,0.00005325624,0.0002315855,0.00005625328,0.0002727384,0.003791002,0.009735811,0.05306506,0.921581],"study_design_scores_gemma":[0.000009854498,0.00003765379,0.0002522933,0.001476692,0.0000436665,0.000787644,0.00003617891,0.00007766139,0.0009749848,0.002286335,0.9940019,0.00001509906],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007538732,0.9978307,0.0002594462,0.0003799745,0.0005834104,0.000003815715,0.00002059356,0.00001368291,0.0008329966],"genre_scores_gemma":[0.0007154223,0.996867,0.0002494919,0.0003341393,0.0004219303,0.00000717081,0.0000438104,0.00000311945,0.001357959],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003779919,"threshold_uncertainty_score":0.01264507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333326815254616,"score_gpt":0.2589226758270167,"score_spread":0.2455894076744706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}