{"id":"W3007281053","doi":"10.3390/molecules25040982","title":"Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer’s Disease","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Toronto; Centre for Addiction and Mental Health","funders":"Azrieli Foundation; Canada Research Chairs; Universität Zürich; European Commission; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; National Science Foundation","keywords":"Radiosynthesis; Sulfonium; Positron emission tomography; Chemistry; Metabotropic glutamate receptor 5; Pet imaging; Nuclear medicine; Radiochemistry; Medicine; Biochemistry; Salt (chemistry); Glutamate receptor; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007273663,0.001039901,0.0006130268,0.0006500689,0.0002495961,0.0006466534,0.0006413458,0.0008964199,0.0009475238],"category_scores_gemma":[0.0002024996,0.0004841005,0.0006717342,0.0002479545,0.0004435095,0.0007382734,0.0002533908,0.00177849,0.0005808488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003746203,"about_ca_system_score_gemma":0.0002827265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001021629,"about_ca_topic_score_gemma":0.001490072,"domain_scores_codex":[0.999737,0.00004239992,0.00002832876,0.00005889178,0.00006717973,0.00006616583],"domain_scores_gemma":[0.9998154,0.00002296458,0.00004487889,0.00002796567,0.00004392724,0.00004482444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000112176,0.00004685012,0.0000590473,0.00006617286,0.000008139125,0.00008013724,0.00002090752,0.00008075528,0.9982053,0.0001000886,0.00005481159,0.001165567],"study_design_scores_gemma":[0.00003735998,0.00113598,0.0007090978,0.00002401515,0.00005999616,0.0004705364,0.00003072366,0.0007396985,0.990684,0.00008084993,0.006014747,0.00001300154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9551858,0.01069819,0.02726872,0.0007109383,0.0002229501,0.0005421416,0.001462323,0.0005283412,0.003380614],"genre_scores_gemma":[0.9127439,0.01866947,0.05145583,0.0004298071,0.0001216405,0.0008940616,0.003144616,0.0002934891,0.01224725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001039901,"threshold_uncertainty_score":0.003846765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07109037031554667,"score_gpt":0.3195178983964675,"score_spread":0.2484275280809209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}