{"id":"W3007340233","doi":"10.1074/jbc.ra119.011078","title":"Structural insights into TAZ2 domain–mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of King's College; Dalhousie University; Queen's University","funders":"Medical Research Council; Leukemia and Lymphoma Society; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Queen's University; Government of Canada; McGill University","keywords":"Transactivation; CREB-binding protein; Transcription factor; Biology; Cell biology; Transcription (linguistics); Protein–protein interaction; Ternary complex; HEK 293 cells; Plasma protein binding; Molecular biology; Genetics; CREB; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006737846,0.0002970443,0.0001401848,0.0001014194,0.0002250307,0.0002097845,0.0004172263,0.0002501901,0.0029262],"category_scores_gemma":[0.00006410449,0.0001475495,0.0001988069,0.00009141159,0.0001431438,0.0002111962,0.0001224511,0.000550799,0.0004347664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004437807,"about_ca_system_score_gemma":0.0003032335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00204661,"about_ca_topic_score_gemma":0.002656343,"domain_scores_codex":[0.9999748,0.000003424624,9.383371e-7,0.000004783117,0.000009207529,0.000006753991],"domain_scores_gemma":[0.9999778,0.000005355545,0.000004505569,0.000001541973,0.000002344355,0.000008339432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002948467,0.0001028279,0.00041928,0.000107843,0.00001387447,0.0004047761,0.00004902663,0.001388035,0.9939306,0.001209185,0.0002570189,0.001822713],"study_design_scores_gemma":[0.0003489986,0.0004749437,0.03009235,0.00003665801,0.00007053318,0.001685459,0.0003725742,0.07186358,0.8765835,0.001750673,0.01667694,0.00004383057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910709,0.001154459,0.004081805,0.0002628776,0.00003319851,0.00002358637,0.0002770832,0.0001296483,0.00296648],"genre_scores_gemma":[0.9954039,0.0004505096,0.002089462,0.00006345952,0.000006444279,0.00001096188,0.0003408365,0.00001116429,0.001623235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0029262,"threshold_uncertainty_score":0.009789109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02484724556250981,"score_gpt":0.2423888488510889,"score_spread":0.2175416032885791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}