{"id":"W3007362882","doi":"10.1101/2020.01.29.20019539","title":"Amyloid-β CSF/PET discordance vs tau load 5 years later: It takes two to tangle","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Vrije Universiteit Amsterdam; Genentech; IXICO; H. Lundbeck A/S; Servier; Pfizer; BioClinica; Biogen; Alzheimer Nederland; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; International Atomic Energy Agency; Meso Scale Diagnostics; Alzheimer's Association; Amsterdam Neuroscience; Foundation for the National Institutes of Health","keywords":"Medicine; Internal medicine; Amyloid (mycology); Tau pathology; Dementia; Pet imaging; Cerebrospinal fluid; Oncology; Cognitive impairment; Biomarker; Pathology; Positron emission tomography; Psychology; Nuclear medicine; Alzheimer's disease; Disease; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001893903,0.000453814,0.000620114,0.0006944591,0.0003970622,0.001247286,0.0005317904,0.0008831178,0.002009974],"category_scores_gemma":[0.006230453,0.000368164,0.0008520071,0.0004805848,0.0002859497,0.001037353,0.0005570185,0.001073409,0.0004025717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003200806,"about_ca_system_score_gemma":0.00028112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002850776,"about_ca_topic_score_gemma":0.002497052,"domain_scores_codex":[0.9993419,0.000119274,0.00006506773,0.0002785042,0.00009078359,0.0001045347],"domain_scores_gemma":[0.9957845,0.001099105,0.00188297,0.0004774935,0.0003567963,0.0003991415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002536062,0.00006821394,0.9926057,0.00001991457,0.0002719937,0.0001831011,0.0001259382,0.0001244233,0.0007106687,0.00003102635,0.0001102707,0.003212754],"study_design_scores_gemma":[0.00002793402,0.0005119889,0.996703,0.00001972908,0.0001996479,0.0005388463,0.0002028416,0.000986964,0.0003745943,0.000169205,0.0002524234,0.00001299253],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990366,0.0003528226,0.0001408581,0.00003316149,0.000009916953,0.000003241162,0.0002144694,0.000007010604,0.0002019482],"genre_scores_gemma":[0.9991682,0.00004956841,0.00007118593,0.00001743272,0.00001539295,0.000005132723,0.0004091224,0.00000353218,0.000260594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002850776,"threshold_uncertainty_score":0.01001608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03177387051395217,"score_gpt":0.3378100462573693,"score_spread":0.3060361757434171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}