{"id":"W3007397555","doi":"10.1016/j.ygyno.2019.11.045","title":"Safety and Efficacy Results of Retreatment With a PARP Inhibitor Monotherapy in Late-Line Recurrent Ovarian Cancer: Results From a Subset of the QUADRA Trial","year":2020,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; PARP inhibitor; Internal medicine; Adverse effect; Ovarian cancer; Oncology; Clinical trial; Cancer; Poly ADP ribose polymerase; Surgery; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005707883,0.0002510026,0.001049182,0.00007825171,0.0000490977,0.000004354663,0.0001641709,0.0003049123,0.0001104055],"category_scores_gemma":[0.000756369,0.000154874,0.0001065774,0.0004927187,0.0003571268,0.00003631122,0.00006366205,0.0003917521,0.000002092853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005191848,"about_ca_system_score_gemma":0.0007869422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001016753,"about_ca_topic_score_gemma":0.002115705,"domain_scores_codex":[0.9971151,0.0005201861,0.0012234,0.0005840528,0.0002712647,0.0002859766],"domain_scores_gemma":[0.9969931,0.001457786,0.0008593636,0.0004252204,0.0001229114,0.0001416119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9325185,0.002059792,0.005215128,0.0000454148,0.0003741768,0.00009838233,0.00773641,0.0006984756,0.004428304,0.00008729485,0.001442153,0.04529599],"study_design_scores_gemma":[0.7784424,0.04767078,0.1104192,0.0005075854,0.0003155176,0.00001004827,0.000448371,0.0007600115,0.01561687,0.0004647122,0.04497695,0.0003675504],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.958315,0.0006202183,0.00002071977,0.0366808,0.0004453757,0.002187998,0.001058599,0.00003305758,0.000638262],"genre_scores_gemma":[0.9951781,0.001967736,0.0009853886,0.001273468,0.0002849699,0.0001341674,0.0001114638,0.00001770323,0.00004697419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1540761,"threshold_uncertainty_score":0.6315576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05037637286026122,"score_gpt":0.3320429756358292,"score_spread":0.281666602775568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}