{"id":"W3007454141","doi":"10.1093/jcag/gwz047.201","title":"A202 DYSREGULATED ENDOPLASMIC RETICULUM STRESS PATHWAYS IN COLON-DERIVED ENTEROIDS FROM INFLAMMATORY BOWEL DISEASE PATIENTS DRIVE DC MATURATION LEADING TO A PRO-INFLAMMATORY PHENOTYPE","year":2020,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Unfolded protein response; Endoplasmic reticulum; XBP1; Cytokine; CD80; Thapsigargin; Cell biology; Inflammatory bowel disease; Immune system; Inflammasome; Biology; Immunology; Inflammation; Medicine; Internal medicine; CD40; Cytotoxic T cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009005658,0.0002976098,0.0003315399,0.0003173042,0.0002073706,0.0002970276,0.00008779218,0.0002697573,0.004339307],"category_scores_gemma":[0.0001678239,0.0001207671,0.0002452967,0.000223453,0.0001884857,0.0001739598,0.0002333647,0.0005495321,0.0007230024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001397508,"about_ca_system_score_gemma":0.00009869569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000213688,"about_ca_topic_score_gemma":0.000264922,"domain_scores_codex":[0.9998666,0.00001752147,0.00001956515,0.00004801187,0.00001941939,0.00002886621],"domain_scores_gemma":[0.9998713,0.00001456501,0.00003930464,0.00001314824,0.00001781915,0.00004397531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00230161,0.0001185436,0.01583819,0.0001791213,0.00002682898,0.001225922,0.0001013491,0.00003302143,0.9762259,0.00003469439,0.0002358658,0.00367903],"study_design_scores_gemma":[0.0004208231,0.004121006,0.6342196,0.00008529515,0.0002058519,0.01908369,0.00138125,0.0008256866,0.328816,0.0002510846,0.01055517,0.00003454932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978319,0.0008275018,0.0003472631,0.00009009089,0.00002706283,0.00001645805,0.000452486,0.00002420381,0.0003830271],"genre_scores_gemma":[0.9972219,0.0003910295,0.0004387671,0.000103866,0.00001903387,0.00002995888,0.0008491802,0.00001089218,0.0009353503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004339307,"threshold_uncertainty_score":0.01451641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004681954566305006,"score_gpt":0.1853357522248987,"score_spread":0.1806537976585937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}