{"id":"W3007468322","doi":"10.1007/s10237-020-01307-6","title":"Study of the combined effects of PTH treatment and mechanical loading in postmenopausal osteoporosis using a new mechanistic PK-PD model","year":2020,"lang":"en","type":"article","venue":"Biomechanics and Modeling in Mechanobiology","topic":"Bone health and osteoporosis research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Anabolism; Osteoporosis; Medicine; Bone remodeling; Pharmacokinetics; Postmenopausal women; Pharmacodynamics; Internal medicine; Parathyroid hormone; Endocrinology; Reduction (mathematics); Bone formation; Urology; Mathematics; Calcium; Geometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002158545,0.0004284242,0.0006922191,0.0002909759,0.0001960388,0.0004264387,0.0007207546,0.0007727934,0.001662171],"category_scores_gemma":[0.0005082764,0.0002259321,0.0006818332,0.0001863433,0.0004497617,0.0004150261,0.000362816,0.0005000918,0.0001143157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001889323,"about_ca_system_score_gemma":0.000529291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001816319,"about_ca_topic_score_gemma":0.001168062,"domain_scores_codex":[0.9999411,0.00001436584,0.000002877945,0.00001443106,0.00001715638,0.00001010636],"domain_scores_gemma":[0.999848,0.00006432334,0.00004071349,0.00001260841,0.00002029083,0.0000140598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002683308,0.0003399124,0.000974485,0.0001923469,0.00006783935,0.0002602384,0.00005222773,0.9325414,0.04098462,0.01759142,0.0003243161,0.006402911],"study_design_scores_gemma":[0.00002920606,0.00007804773,0.0004302928,0.000003017455,0.0000262125,0.00003609319,0.000009541161,0.9965377,0.00118762,0.001407062,0.0002493187,0.000005853457],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7269376,0.001025085,0.243711,0.0008234135,0.0001370625,0.000159047,0.0004184916,0.000196708,0.02659158],"genre_scores_gemma":[0.9892328,0.000320585,0.007069204,0.0000402443,0.000013955,0.00006330985,0.0000454603,0.00001296213,0.003201492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001816319,"threshold_uncertainty_score":0.005560517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09591352272892945,"score_gpt":0.3379670306122036,"score_spread":0.2420535078832742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}